Principal Scientist Jobs

Job Title: Pharmaceutical Chemist Company: Lachman Consultants Location: US and International , ZZ Description: PHARMACEUTICAL CHEMISTS: Lachman Consultants, a worldwide, renowned pharmaceutical consulting firm is looking for: FORMER FDA INVESTIGATOR CHEMISTS OR PHARMACEUTICAL INDUSTRY CHEMISTS / SUPERVISORS FOR INDEPENDENT CONSULTING OPPORTUNITIES: Chemists must have experience in performing GMP / GLP audits covering laboratory procedures and practices for Quality Control, Bioanalytical and Analytical Research and Development Laboratories; documentation practices; analytical methods development, validation and transfer; instrument qualification; training programs; stability studies, investigations; CAPAs, etc. and assist in project management. Experience must also include electronic data reviews, remediation of laboratory control systems, laboratory investigations including OOS and mitigation, deviations, and change control records. Quality Assurance or Regulatory Agency experience a plus. Qualifications: B.S. / M.S. / Ph.D. in Chemistry Minimum of 10 years' laboratory experience, preferably in a Quality Control setting Detailed knowledge of current FDA, ICH, and USP regulations / guidances and expectations Strong communication / presentation skills, verbal and written, are required for interaction with clients and coworkers Ability to recognize and differentiate importance of issues and prioritize accordingly All candidates must have verifiable and recent "hands on" experience, including demonstrated remediation skills in the pharmaceutical industry. Only competent, well qualified, and highly motivated chemists with a proven track record of success need submit resume for consideration to be engaged as an independent consultant. Must be willing to travel both domestically and internationally. Send resume which includes dates of employment history to Register to View

Job Title: LABORATORY MANAGER Company: Matheson Tri-Gas, Inc. Location: New Johnsonville, TN Description: LABORATORY MANAGER Matheson Inc. is seeking a Laboratory Manager for our New Johnsonville, Tennessee facility. The Laboratory Manager is responsible for the day-to-day operations of the facility including all aspects of Data Generation and Reporting, Staffing, Financial Performance, Quality, Customer Service, and Environmental Health and Safety.This is a full-time, exempt position with a starting salary commensurate with experience. Relocation allowance is available to the right candidate.The New Johnsonville laboratories analyze a wide variety of specialty and electronic gas products. Analytical equipment utilized includes gas chromatographs, atomic absorption, FTIR, CRDS, and various process analyzers.The ideal candidate will possess: A relevant science degree with a minimum of 7 years experience working in a specialty, electronics or environmental laboratory operation with progressive responsibilities, including personnel management. Familiarity with a wide variety of bench level techniques, processes, equipment and data systems for routine environmental testing procedures. Demonstrated experience leading or managing a team at the department and/or laboratory level. The ability to relate professionally with people through both verbal and written communications. Excellent time management and organizational skills with the ability to handle multiple priorities simultaneously, and operate in a fluid environment while managing and coordinating projects and staff. Familiarity with ISO Accreditation and Quality Programs A high degree of motivation to lead a laboratory team to meet stated Goals and Objectives. Excellent compensation & benefits package, including medical, dental, vision, 401(k) Retirement Savings Plan with employer match. Send resume & salary requirements. to: Matheson Tri-Gas, Inc., Attn: H.R. Manager, Fax: Register to View or e-mail: HR- Register to View -Trigas.com No phone calls or agencies please. EOE M/F/D/V MATHESON TRI-GAS www.matheson-trigas.com

Job Title: SR CHEMIST Company: Professional Services of America Inc. Location: Beltsville, MD Description: The government has a need for chemist services to develop analytical methods and protocols on tobacco products in support of the Bureau's enforcement programs. GOVERNMENT-FURNISHED PROPERTY, EQUIPMENT and SUPPLIES Existing workspace, utilities, furniture, laboratory equipment, laboratory supplies and personal safety equipment except for prescription eyewear. Task specific training such as training on theory and operation of analytical equipments, such as a smoking machine, as well as general training on the following SSD Technical Procedure Document (TPD) and Quality Procedure Document (QPD)

Job Title: Senior Scientist/ Principal Scientist Membrane Protein Chemistry (Takeda San Diego) Company: Takeda Pharmaceuticals N. Amer Location: San Diego, CA Description: Please note that the requirements specified in this posting are the basic qualifications required for theSenior Scientist position; however, job title will be dependent on the candidate's level of experience in those requirements. OBJECTIVE: Independently establishes and exploits state-of-the-art equipment and processes to express and then highly purify membrane proteins (e.g. integral membrane proteins, GPCRs, ion channels and membrane-associated proteins) and their complexes with agonists and/or antagonists for crystallographic analysis to support further design of drug candidates. Highly purified proteins also support assay development and compound screening at TSD or other Takeda sites. ACCOUNTABILITIES: - Recommends, designs and executes experiments to complete the company goals and become an industry leader in membrane protein structural biology - Independently performs hands-on small-scale and large-scale purification of membrane proteins using state-of-the-art methods and technologies to support crystallization. Establishes and incorporates bioanalytical and biochemical assays to measure and optimize stability and functionality of membrane proteins during and after purification such as (but not limited to) enzymatic assays, protein/detergent/lipid characterization studies, time-dependent stability studies. - Performs hands-on small-scale and large-scale expression optimization of membrane proteins. Uses state-of-the art technologies to monitor and optimize expression parameters as well as to optimize protein yields to support crystallization and assay development. - Performs hands-on crystallization of membrane proteins using LCP, hanging/sitting/sandwich drop techniques and/or other state-of-the-art crystallization techniques. Optimizes protein and/or crystallization conditions through detergent/lipid/protein and precipitant screening and optimization to support formation of diffraction-grade crystals. - Independently designs and works out purification conditions to obtain highly purified, functional and stabilized membrane protein material to support discovery biology groups and supply protein for assay development and compound screening. - Generates own ideas for protein expression, purification and crystallization strategies of membrane proteins and motivates, inspires, and educates other structural biology team members. - Provides input and feedback to the molecular biologist, protein chemists and crystallographers in our team or within the organization on new protein boundary designs, incorporation of mutations that alter protein function and stability and on new ideas to improve protein expression and purification yields, crystallizability and diffraction quality of membrane protein crystals. - Proactively seeks out new data and new technologies and incorporates them into the lab. Proactively identifies membrane protein targets that will be most suitable for structure analysis and structure-based drug design. - Creates relevant intellectual property for the company and contributes to patent authorship or authorship of scientific manuscripts, frequently as principal author. - May mentor Research Scientists and Research Associates. - Participates and presents own research to internal management and/or external collaboration teams. Please note that the requirements specified in this posting are the basic qualifications required for theSenior Scientist position; however, job title will be dependent on the candidate's level of experience in those requirements. EDUCATION, EXPERIENCE AND SKILLS: - Ph.D. in life science with thesis, publication(s) and minimum 5 years of relevant experience in membrane protein chemistry, OR - MS in life science with minimum 11+ years of relevant experience, OR - BS in life science with minimum 14+ years of relevant experience - Proven track record in membrane protein structural biology with > 5years of expert knowledge and hands-on experience in successful expression, purification, bioanalytical and biochemical characterization of membrane proteins using state-of-the art technologies. - Proven in-depth knowledge and expertise in membrane protein biology demonstrated preferably through principle authorship in peer-reviewed publication(s). - Demonstrated independent thought/creativity in science and able to convey ideas in an experimentally detailed yet scientifically concise manner. - Excellent collaboration, communication and multitasking skills and able to present work formally to Research Committee and/or other Takeda groups. - Expert knowledge of applicable state-of-the-art lab equipment. - Possesses a high degree of scientific discretion/intuition PHYSICAL DEMANDS: - Prolonged standing and/or sitting - Manual dexterity required to operate office and heavy lab equipment - Carrying, handling and reaching for objects - Working in cold room (4C) - Exposure to hazardous/toxic/dangerous chemicals TRAVEL REQUIREMENTS: - May travel to various domestic conferences or client sites, including overnight trips. Some international travel may be required. - A minimum of 2% travel. Submit your resume and start a quality career with Takeda! We are an equal opportunity employer. www.takedasd.com www.tpna.com No Phone Calls or Recruiters Please.

Job Title: Principal Scientist - Technical Transfer Company: Johnson & Johnson Consumer Inc. (6071) Location: Skillman, NJ Description: Johnson & Johnson Consumer & Personal Products Worldwide, a member of Johnson & Johnson's Family of Companies is recruiting for a Principal Scientist located in Skillman, NJ. Johnson & Johnson Consumer Products Company Division of Johnson & Johnson Consumer Companies, Inc. develops and markets baby care, wound care and skin care products that address the needs of consumers and health care professionals and incorporate the latest innovations. The portfolio includes heritage brands JOHNSON'S Baby and BAND-AID Brand, as well as leading skin care brands such as AVEENO and CLEAN & CLEAR. We are currently recruiting for a Principal Scientist to support Technical Transfer in Skillman, NJ. The PrincipalScientist will support a broad range of consumer products such as Skin Care, Beauty Care, Baby Care, Oral Care, Wound Care and Women's Health Care from a manufacturability and formulation standpoint. The Principal Scientist will collaborate cross-functionally with Operations, Marketing, Quality Assurance, and Research and Development (R&D) to identify opportunities, build business cases and perform the work necessary to realize product cost and process improvements. The scope of work includes Process Development/ Process Scale-up, Specification Development, leadership, manufacturing process improvements, and process validation. The Principal Scientist is expected toidentify opportunities, execute technical aspects of projects, interact with and/or lead cross-functional teams to implement projects. The individual will work independently to drive technical resolutions in manufacturing and troubleshoot product issues under compressed timelines.QualificationsIt is required that the candidate have a Masters in Chemistry or related scientific discipline with 7 years of consumer industry experience OR a PhD in Chemistry or related scientific discipline with 5 years of consumer industry experience. Microsoft Office proficiency is required. Experience with consumer products, such as skin care, skin cleansers, hair care, oral care, baby care and/or deodorant products is highly desired. It is required that the candidate will possess a good technical foundation of formulated products including emulsions, surfactants, suspensions, structured liquids and an understanding of material chemistry. Familiarity with cGMP and other regulatory requirements is desired. Experience working with external manufacturers is preferred. Previous experience building relationships with cross functional teams while being an individual contributor is required. Excellent oral and written communication skills and solid presentation skills are required. The ability to support multiple, high-complexity projects and deliverables from beginning to end, while meeting aggressive timelines, is required. This position will require 10% travel and is based in Skillman, NJ. If you want to explore the many small-company environments behind the big-company impact of the Johnson and Johnson Family of Companies, bid on this position today!

Job Title: Merck Consumer Care Sr. Principal Scientist (Memphis, TN)-CHC000010R Company: Merck & Co. Inc. Location: Memphis, TN Description: Merck Consumer Care Sr. Principal Scientist (Memphis, TN)-CHC000010R Description Merck is a global health care leader with a diversified portfolio of prescription medicines, vaccines and consumer health products, as well as animal health products. Today, we are building a new kind of healthcare company - one that is ready to help create a healthier future for all of us. Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you'll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career. Using broad-based knowledge in the pharmaceutical sciences, the selected individual is responsible for the formulation of consumer healthcare products. The successful candidate will direct the formulation activities for a variety of product lines and dosage forms as well as lead cross-functional teams to progress the projects through all developmental stages to commercialization. Responsibilities include but are not limited to: Responsible for the scientific leadership of projects to drive new product development; leads cross-functional teams Applies advanced scientific concepts to complex problems Develop formulations and manufacturing processes for various dosage forms for new chemical entities and line extensions Designs experimental protocols and carries out relevant experiments May scale up the manufacturing process for pilot plant production Prepares stability, clinical and toxicology batches according to GMP/GLP. Prepares and/or reviews the appropriate documents for regulatory submission as well as technical reports Applies in-depth scientific knowledge and maintains awareness of new developments in the field Directs/manages activities of junior scientists Qualifications Education Required: Ph.D. in Pharmaceutical Science required Required Skills and Experience: 10 years product development experience in the pharmaceutical industry or consumer healthcare required Advanced knowledge of pharmaceutical product and process development Ability to initiate new experimental approaches and related work processes and procedures Strong problem solving skills Excellent oral and written communication skills, including technical writing Previous experience managing lower-level scientists Effective at building teams Our employees are the key to our company's success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Merck's benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives. To be considered for this position, please visit our career site at www.merck.com/careers to create a profile and submit your resume for requisition # CHE000010R. Merck is an equal opportunity employer, M/F/D/V - proudly embracing diversity in all of its manifestations. Search Firm Representatives Please Read Carefully: Merck is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Merck via-email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck. No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.

Job Title: Principal Scientist Immunology Company: Boehringer Ingelheim GmbH Location: Ridgefield, CT Description: Design and implement strategies for the identification, optimization and characterization of antibody-based therapeuticsActively participate in and/or lead antibody-based drug discovery project teamsManage a group of 2 scientists to ensure high quality results and timely project supportEffectively collaborate with colleagues in the antibody engineering and characterization groupsParticipate in the evaluation of biologic-based therapeutic technologiesMaintain excellent communication within the Immunology & Inflammation Dept. and across all research project teams and departmentsEnsure all R&D activities are conducted in accordance with BIPI regulations and safety procedures and practices

Job Title: Principal Scientist, Technical Transfer (1 of 2) Company: Johnson Location: Los Angeles, CA Description: Title: Principal Scientist, Technical Transfer (1 of 2) Location: California-Los Angeles Neutrogena Corporation develops, manufactures and markets premium skin and hair care products sold worldwide and recommended by medical professionals. The regulatory classification of the products is principally OTC drug. The product line includes acne treatment products, sun protection, facial care as well as other hair and skin care products. Neutrogena Corporation is recruiting for a Principal Scientist to support Technical Transfer in Los Angeles, CA. The Principal Scientist will support a broad range of consumer products from a manufacturability and formulation standpoint. The Principal Scientist will collaborate cross-functionally with Operations, Marketing, Quality Assurance, and Research and Development (R&D) to identify opportunities, build business cases and perform the work necessary to realize product cost and process improvements. The scope of work includes Process Development/ Process Scale-up, Specification Development, leadership, manufacturing process improvements, and process validation. The Principal Scientist is expected to identify opportunities, execute technical aspects of projects, interact with and/or lead cross-functional teams to implement projects. The individual will work independently to drive technical resolutions in manufacturing and troubleshoot product issues under compressed timelines. It is required that the candidate have a Masters in Chemistry or related scientific discipline with 7 years of industry experience OR a PhD in Chemistry or related scientific discipline with 5 years of industry experience. Microsoft Office proficiency is required. Experience with consumer products, such as skin care, skin cleansers, hair care, oral care, baby care and/or deodorant products is highly desired. It is required that the candidate will possess a good technical foundation of formulated products including emulsions, surfactants, suspensions, structured liquids and an understanding of material chemistry. Familiarity with cGMP and other regulatory requirements is desired. Experience working with external manufacturers is preferred. Previous experience building relationships with cross functional teams while being an individual contributor is required. Excellent oral and written communication skills and solid presentation skills are required. The ability to support multiple, high-complexity projects and deliverables from beginning to end, while meeting aggressive timelines, is required. This position will require 10% travel and is based in Los Angeles, CA. If you want to explore the many small-company environments behind the big-company impact of the Johnson and Johnson Family of Companies, bid on this position today!

Job Title: Principal Scientist - Protein Expression Company: Virdante Pharmaceuticals Location: Cambridge, MA Description: The candidates primary responsibility is to develop and transfer recombinant protein expression cell lines for antibody products and glycosyltransferase enzymes for early clinical (Phase I, II) through late-stage/commercial manufacturing. The successful candidate will plan and execute laboratory scale experiments and will also support technology transfer of all cell-based processes to GMP manufacturing sites. The job is complex, requiring an in depth understanding of the biological and chemical properties of human antibodies, glycosyltransferase enzymes, and recombinant protein expression in a variety of expression hosts systems. The candidate is expected to posess solid knowledge about human glycosylation properties and platforms for the recombinant production of proteins, including monoclonal antibodies. The candidate will be a key contributor during technology transfer of all recombinant cell line processes. The candidate will be expected to independently design and execute experimental and theoretical studies within the scope of projects defined by management. The person will be expected to display sense of urgency while completing critical tasks and effectively manage his/her time. The candidate will also be expected to provide novel solutions to complex problems while attaining a good balance between theoretical, experimental and practical approaches. The candidate is expected to provide concise, high quality technical reports and presentations to management and external groups and contribute to the preparation of regulatory filings. The candidate will work closely with groups such as process development, analytical development and with external vendors, including contract manufacturing organizations. REQUIREMENTS: Education & Experience: PhD in Molecular or Cellular Biology, Biochemistry or related discipline with 4 to 7 years relevant professional experience. Candidate must have excellent knowledge and experience in recombinant protein expression in mammalian and microbial systems, especially with respect to strain/ host cell development and engineering. Prior experience in glycosyltransferase enzyme engineering and soluble expression is highly desirable. Demonstrated record of publication, conference attendance, and/or patent authorship exhibiting outstanding competency in protein engineering and recombinant biologics expression is essential. Candidates must have excellent problem solving skills and demonstrated ability to work in a fast paced multi-disciplinary team environment. Experience working with groups such as process development, analytical development, and external GMP contract organizations is desirable. Key Skills & Competencies: The candidate must have a working knowledge of molecular and cellular biology techniques such as modular protein domain structure-function, computational prediction of secondary and tertiary structure, ligand-protein docking simulations, immunogenicity, mutagenesis strategies, molecular probes and reporters, chimeric fusions, domain grafting, and modulation of protein stability and localization. The candidate must be familiar in statistical design of experiment (DOE) methods, statistical data analysis and must have the ability to assimilate and interpret data collected. Prior experience in protein biochemistry and immunological methods such as immunocytochemistry, immunoprecipitation, ELISA, western blot analysis, quantitative enzyme assays, SDS page and isoelectric focusing is required. The candidate must demonstrate excellent written and verbal communication skills, including excellent documentation skills.

Job Title: Development Microbiologist (Principal Scientist I) Company: AstraZeneca Pharmaceuticals Location: Boston, MA Description: Watch our employee profile video to learn more about what is it like to work at AstraZeneca Length: 1:00 min You can at AstraZeneca. AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity. We have received many honors, including: Fortune World's Most Admired Companies list (2009) Woman Engineer Magazine's 18th Annual "Top 50 Employers" (2008) The Times Top 100 Graduate Employers (2007-2008) CEO Cancer Gold Standard Reaccreditation, CEO Roundtable on Cancer (2008 & 2009) 100 Best Companies for Working Mothers by Working Mother Magazine (2002 - 2008) 100 Best Companies to Work For in America by Fortune Magazine* (2008) *Only large pharmaceutical company included on the list Diversity MBA Magazine Top 50 Companies in Diversity Leadership (2008) Men's Fitness Top 15 Fittest Companies in America (2008) The Scientist Best Places to Work in Industry (2008) Fit-Friendly Company Award, American Heart Association (2007) Top Employer, Science Magazine (2002 - 2007) Development Microbiologist (Principal Scientist I) Job Summary Responsibilities Description: Operational development microbiology in support of antibacterial global product teams: works with Development Microbiology Directors; and Clinical, Regulatory, Commercial and Discovery Medicine colleagues to create and deliver clinical and non-clinical microbiology plans and reports of experimental and review work in an outsourcing model. Depending on experience: might support Clinical Project Teams as Development Microbiology representative. Major Responsibilities [it is recognized that the successful candidate might not have experience of all of these activities: see minimum requirements] Create plans for delivery of the agreed microbiology strategies of global product teams using an outsourcing model, and forecast the resources needed (FTEs, $$). Work with the microbiology standards agencies, CLSI and EUCAST, and susceptibility-testing device manufacturers, to implement the project's susceptibility-testing and breakpoint strategy. Deliver the clinical and non-clinical microbiology plans using an outsourcing model. Contribute to microbiology sections of regulatory submissions (NDA, MAA, etc), core data sheets, and product labels. Write microbiology sections of investigator brochures, in collaboration with colleagues from other functions. Work with purchasing and legal colleagues to set up contracts for external work with appropriate external providers and medical and scientific experts; performing due-diligence investigations as appropriate. Make presentations of completed work and proposed plans to clinical project teams, the research management team, global product teams, and discovery colleagues as required. Analyze the competitive environment for specific antibacterial compounds in clinical development under the guidance of Development Microbiology directors. In collaboration with colleagues in medical affairs and other commercial functions, provide scientific summaries to support the launch of new antibacterial compounds. Be proficient in the use of relevant software tools at AstraZeneca. Qualifications PhD in microbiology, infection pharmacology, or a related discipline and experience of publishing relevant research in the academic literature. -5 or more years experience in the microbiology of the clinical development of antibacterial agents. Familiarity with the work of CLSI and EUCAST. Working knowledge of internet search tools such as Pubmed, Highwire, Google scholar, Science direct, Scifinder etc. Experience of creating good scientific proposals and presenting them authoritatively at project meetings. Skills and Competencies Can address the needs of multiple customers: development microbiology directors and colleagues, project team and discovery medicine colleagues, doctors, regulators and patients. Holds self and others accountable. Self-development orientation: can listen to and respond to feedback and provide constructive feedback to others. Ability to work under pressure and to deadlines. Good collaborator: respects and integrates different views. Ability to analyze data and make consequent recommendations for action. Results orientation. Preferred Background PhD in microbiology and a publication track record. Seven or more years' experience in the microbiology of the clinical development of antibacterial agents. Experience of preparing microbiology plans to support antibacterial drug development projects, including planning non-clinical microbiology in accordance with the project strategy and regulatory guidance. Experience of conducting the microbiology associated with clinical trials. Experience at presenting microbiology work to project teams to monitor progress against agreed strategies. Knowledge of key members of CLSI and EUCAST, and microbiology outsource provider companies. Knowledge of antibacterial PK-PD. We want you to build a balanced life at AstraZeneca. Your career is just one part of that. We offer competitive salaries, rewards and recognitions for your invaluable time and efforts. We also bring you all the things you need to for your life outside of your work: generous health and welfare benefits flexible scheduling child care programs learning and development opportunities fitness centers and other personal conveniences At AstraZeneca, we put people first. Whether it's the patients we help or the employees who make everything we do possible. AstraZeneca is an equal opportunity employer. Visit AstraZeneca's Online Recruitment Center to complete a profile and apply