Associate Scientist for Center for Advanced Genome Engineering (CAGE)

The World's Brightest Minds Always Innovate

At St. Jude Children's Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That's why we provide world-class facilities, state-of-the-art technologies, and extraordinary support for your research to ensure scientific progress is never halted from a lack of resources. At St. Jude, you will be part of a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve.

This is an exciting opportunity for an Associate Scientist to join our Center for Advanced Genome Engineering (CAGE). Our laboratory offers a strong team-based environment where you will work collaboratively with other investigators across the institution to support their research needs and develop and improve genome engineering technologies. As a member of this laboratory, you will bring in cutting edge protocols to provide newer and better workflows to our genome engineering operations, perform research focused on improving gene editing techniques and developing new ones, and aid St. Jude investigators by creating custom genome-modified cell lines.

Your expertise in programming with Python/R and familiarity with cluster environments will enable you to develop new programs as well as integrate published processes to aid the CAGE with genome engineering. A successful candidate for this position will have a proven track record of driving a research project to completion, have a strong ability to multitask, and, perform complex, multidisciplinary, long-term experiments. This individual should be able to identify gaps in experimental design and independently incorporate new methods and protocols.

The Ideal Candidate will have:

• Expertise in cell and molecular biology.
• Computer programming experience (Python, R, computing clusters, and bioinformatic workflows).
• Expert in developing and validating new protocols/procedures.
• Excellent multi-tasking skills.
• Strong ability to perform independent research and interpret complex research data and generate novel solutions.
• Ability to monitor data integrity.
• Experience with genome engineering.
• A proven record of driving a project to completion.
• Excellent verbal and written communication skills.
• Next generation sequencing library preparation and analysis experience a plus.
• Supervisory experience a plus.
• CRISPR/shRNA screening experience a plus.

Job Responsibilities:

• Independently perform experiments using existing, modified, or newly developed techniques/ protocols.
• Set up protocols using new or modified laboratory techniques and troubleshoot experiments independently.
• Identify experimental data pertinent to the analysis problem; process, organize, and summarize data; report results.
• Assist in the drafting and editing of manuscripts, posters, SOPs, and policies.
• Maintain up-to-date knowledge of the field and related techniques.
• Provide ongoing support for monitoring, maintenance, ordering, and purchasing of equipment and supplies as needed.
• Perform calibration of instruments and equipment as necessary.
• Provide guidance and training to less-experienced team members and may also train others outside lab in relevant techniques.
• Perform other duties as assigned to meet the goals and objectives of the department and the institution.
• Maintain regular and predictable attendance.

Minimum Education and/or Training:

• Bachelor's degree in a relevant scientific area

Minimum Experience:

• 7 + years of research experience is required
• 5 + years of research experience is required with a Master's degree
• 2 + years of research experience is required with a PHD
• Experience leading and supporting research experiments preferred
• Some experience leading lab and scientific project coordination, maintenance, and other research support activities preferred
• Experience in guiding and training other laboratory personnel preferred
• Proven performance in earlier role/comparable role
• Eligibility for employees who transitioned into, were hired, or accepted offers for the role before 1/5/2025, the effective date of the Lab Research Career Path Refinements, will be determined based on the following criteria: Bachelor's + 5 years; Master's + 3 years; PHD + 0

Compensation
In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $65,520 - $114,400 per year for the role of Associate Scientist for Center for Advanced Genome Engineering (CAGE).

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St. Jude is an Equal Opportunity Employer

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