Senior Scientist, CAR Screening and Lead Selection (Cell & Genetic Medicines Discovery)

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at

**Job Function:**

Discovery & Pre-Clinical/Clinical Development

**Job Sub** **Function:**

Biotherapeutics R&D

**Job Category:**

Scientific/Technology

**All Job Posting Locations:**

Cambridge, Massachusetts, United States of America

**Job Description:**

**About Innovative Medicine**

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at

We are searching for the best talent for **two** **Senior Scientist, CAR Screening and Lead Selection (Cell and Genetic Medicines Discovery)** that will be based in Cambridge, MA.

**Purpose:**

We are seeking a highly motivated and technically skilled Senior Scientist to join our CAR Screening and Lead Selection team focused on advancing next-generation cell therapies. The Senior Scientist will design, execute, and analyze in vitro assays to characterize CAR-T candidates, supporting data-driven decisions that drive pipeline progression. This role offers the opportunity to work cross-functionally in a dynamic, fast-paced environment with cutting-edge technologies.

**Responsibilities:**

+ Design, perform, and troubleshoot complex in vitro assays, including flow cytometry-based immunophenotyping and functional assays to evaluate CAR-T activity.

+ Develop and execute IncuCyte-based cytotoxicity assays to assess cell killing and persistence.

+ Maintain meticulous records of experimental design, data, and analysis using Benchling electronic lab notebook (ELN).

+ Analyze and visualize complex datasets using GraphPad Prism and other visualization tools; clearly communicate results in team meetings and reports.

+ Collaborate closely with colleagues in discovery, process development, and therapeutic area teams to align priorities and share data.

+ Contribute to experimental design discussions and provide technical guidance to junior team members.

+ Ensure laboratory operations follow best practices for safety, data integrity, and reproducibility.

**Qualifications:**

+ PhD in immunology, cell biology, or a related field with 2+ years of relevant industry or postdoctoral experience; OR a BS or MS with 4-6 years of experience will also be considered.

+ Extensive hands-on experience with multiparameter flow cytometry, including panel design, sample preparation, acquisition, and data analysis.

+ Proficiency in IncuCyte-based assays or comparable real-time cytotoxicity platforms.

+ Demonstrated expertise using ELN systems for experimental documentation, experience with Benchling a plus.

+ Advanced skills in data analysis and visualization using GraphPad Prism, Spotfire or similar software.

+ Strong problem-solving skills and the ability to independently drive projects while working collaboratively.

+ Excellent written and verbal communication and presentation skills.

+ This is an on-site lab-based role; candidates must be comfortable with extensive bench work and collaborative team science.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected vertebras and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center ( ... ) or contact AskGS to be directed to your accommodation resource.

**The anticipated base pay range for this position is :**

$105,000 to $169,050

Additional Description for Pay Transparency:

Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance. Employees may be eligible to participate in the Companys consolidated retirement plan (pension) and savings plan (401(k)). Employees are eligible for the following time off benefits: Vacation up to 120 hours per calendar year Sick time - up to 40 hours per calendar year Holiday pay, including Floating Holidays up to 13 days per calendar year Work, Personal and Family Time - up to 40 hours per calendar year For additional general information on Company benefits, please go to: - The Company may however extend this time-period, in which case the posting will remain available on to accept additional applications.