Scientist, CAR Screening and Lead Selection (Cell & Genetic Medicines Discovery)

• Job title Scientist, CAR Screening and Lead Selection (Cell & Genetic Medicines Discovery)
• Function Discovery & Pre-Clinical/Clinical Development
• Sub function Biotherapeutics R&D
• Category Experienced Scientist, Biotherapeutics R&D (ST5)
• Location Cambridge / United States of America
• Date posted Jul 17 2025
• Requisition number R-022608
• Work pattern Fully Onsite

Description

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Biotherapeutics R&D

Job Category:

Scientific/Technology

All Job Posting Locations:

Cambridge, Massachusetts, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at

We are searching for the best talent for a Scientist, CAR Screening and Lead Selection, Cell & Genetic Medicines Discovery that will be based in Cambridge, MA.

Purpose:

We are seeking a skilled and collaborative Scientist to join our Cell Therapy CAR Screening group. In this role, you will design and execute in vitro experiments to evaluate CAR constructs, characterize engineered cell products, and generate high-quality data to support pipeline decision-making. You will contribute scientific and technical expertise while working cross-functionally to help advance our next-generation cell therapy programs.

Responsibilities:

• Design, plan, and perform complex in vitro assays to assess CAR-T cell function, including multi-color flow cytometry, IncuCyte-based cytotoxicity, cytokine release, and other functional readouts.

• Analyze, interpret, and communicate experimental data clearly to project teams; contribute to data packages that inform lead candidate selection and progression.

• Develop, optimize, and troubleshoot assay protocols; help maintain and improve SOP documentation to ensure reproducibility and efficiency.

• Maintain detailed experimental records using Benchling Electronic Lab Notebook (ELN).

• Collaborate with colleagues across research, in vivo models, and manufacturing teams to align experimental plans with program goals.

• Provide technical guidance and mentorship to junior staff; foster a culture of scientific rigor, continuous improvement, and teamwork.

• Support preparation of reports, presentations, and other documentation for internal and external stakeholders as needed.

Qualifications:

• B.S. or M.S. in Immunology, Cell Biology, or a related scientific field with 2-4 years of relevant laboratory experience.

• Proven hands-on experience with multi-color flow cytometry, including panel design, instrument operation, and data analysis.

• Experience with IncuCyte or similar real-time cytotoxicity and functional assays strongly preferred.

• Proficiency with ELN systems (experience with Benchling a plus) and data analysis/visualization tools (e.g., GraphPad Prism, Spotfire, etc).

• Strong problem-solving skills, attention to detail, and ability to adapt to evolving priorities.

• Excellent organizational, communication, and collaboration skills; able to work effectively in a matrixed, team-oriented environment.

• This is an on-site lab-based role; candidates must be comfortable with extensive bench work and collaborative team science.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected vertebras and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (...) or contact AskGS to be directed to your accommodation resource.