Senior/Principal Scientist Program Biology & Pharmacology

Senior/Principal Scientist - Program Biology & Pharmacology

City :

Emeryville

State :

CA

Country :

US

Job Term :

Permanent

Overview :

PharmaLogics Recruiting is seeking a Principal Scientist / Associate Director - In Vivo Pharmacology in Emeryville, CA.

Job Description :

Responsibilities

Design sound in vivo efficacy and PK studies to support characterization of lead small molecule candidates and summarize vetted results clearly and concisely

Design, develop, and execute a broad range of cell based functional and phenotypic in vitro assays to understand the mechanism of action and potency of hits identified from DNA encoded library screening

Execute lab-based activities with meticulous sterile technique and attention to detail to support in vitro and ex vivo cell-based assay efforts (e.g. mammalian cell culture, PBMC handling, tissue processing)

Work in teams as the immunology subject matter expert

Develop screening funnels to drive medicinal chemistry efforts towards development candidates and characterize mechanism of action

Coordinate and communicate with CROs on outsourced activities and assist with internal approvals, transfer of assays, materials and/or know-how for execution at external sites

Demonstrate ability to multi-task, organize and execute effectively with competing demands

Think critically about experimental design, outcomes and issues; flag challenges in a timely manner and proactively execute mitigation plans

Summarize and synthesize data across experiments and present findings at all levels of the organization to support data-driven decision making

Provide scientific leadership and mentorship to scientists and research associates

Contribute towards vetting new targets for covalent drug discovery

Work collaboratively and proactively with colleagues in the computational biology, clinical, and platform screening teams in a matrixed team structure

Compensation Details:

The base salary range for this role is $160,000-$190,000. The final compensation will be commensurate with such factors as relevant experience, skillset, internal equity and market factors.

Requirements & Experience :

Qualifications

PhD or equivalent industry experience in immunology, cellular or cancer biology, or a related field for 8-12+ years

Required Skills

Strong background in immunology

Proficiency designing and coordinating in vivo efficacy and PK studies through CROs, including communication, tracking progress, thorough data review and reporting to internal stakeholders. Models include xenograft (PDX, CDX) and immunology/autoimmune disease models

Expertise in primary immune cell culture and developing and executing in vitro and ex vivo cellular assays including immune cell phenotyping, cytotoxicity, proliferation and cytokine analysis

You will have experience in pro-actively planning and managing assay workflows; including organizing time, materials and resources to execute project goals efficiently

Outstanding written and oral communication skills and the ability to organize and communicate complex data sets clearly and concisely to key stakeholders from diverse backgrounds

Experience in leading and organizing cross functional teams

In this lab-based position, you will have an appreciation and respect for laboratory operation, cleanliness, safety and good lab citizenship

Culture is key - you will be part of a dynamic, collaborative and free-spirited organization. In this regard, you will bring a strong growth mindset, a positive can-do attitude and deep curiosity to learn and grow with the company

About Us :

In business since 2003, PharmaLogics Recruiting is a global recruiting firm exclusively focused in life sciences. Our clients range from venture-backed start-ups to Fortune 500 firms, and we match your skills, experience and career aspirations to find you just the right fit. We have the unique opportunity to make a meaningful impact on the future of healthcare by finding the best minds in life sciences (like yours!), and pairing them with both emerging and established companies who are innovating treatments with a variety of organizations, including:

Biotech/Pharmaceutical

Medical Device

Clinical Research Organizations (CROs)

Hospitals, Universities, and Research Sites

Government and Academic Institutions

Why Work With Us :

Life Sciences experts with consultative approach

Deep networks to connect you with the most up-and-coming, recognized positions in your field

Exclusive searches with direct connections to decision makers