Scientist III/Senior Scientist, Biology, Group Leader

Fusion Pharmaceuticals, a member of the AstraZeneca Group, is a clinical-stage oncology company focused on developing next-generation radioconjugates (RCs) as precision medicines. Fusion connects alpha particle emitting isotopes to various targeting molecules to selectively deliver the alpha emitting payloads to tumors. Fusion’s clinical portfolio includes but is not limited to: FPI-2265 targeting prostate specific membrane antigen (PSMA) for metastatic castration resistant prostate cancer currently in a Phase 2 trial; FPI-1434 targeting insulin-like growth factor 1 receptor currently in a Phase 1 trial; and FPI-2068, a bispecific IgG-based EGFR-cMET targeted radioconjugate currently in a Phase 1 trial. Fusion has multiple other pipeline programs that will soon be entering into early FIH trials. In addition, Fusion is pursuing combination programs between RCs and other therapeutic modalities including DNA Damage Response Inhibitors (DDRis) and immune-oncology agents. To support execution for these programs, Fusion has a fully operational Good Manufacturing Practice (GMP) compliant state-of-the-art radioconjugate manufacturing facility to meet supply demand for our growing pipeline of RCs.

The Role: The Scientist III/Senior Scientist, Group Leader is expected to lead the scientific execution of drug discovery projects in alignment with departmental goals and timelines by designing and conducting experiments, setting objectives, delivering on project milestones, along with analyzing, interpreting and communicating results according to timelines.

Responsibilities:

• Lead and mentor a team of junior scientists assigned to their projects/programs and supervise their work

• Provide periodic feedback on staff performance as well as documented yearly performance evaluations

• Laboratory time conducting and participating in studies is expected

• Identify and develop new techniques and assays to expand or enhance existing programs

• Design and conduct biologic screening assays, mechanisms of action studies, therapeutic efficacy and biodistribution studies on radiopharmaceuticals in rodent models of cancer (or other disease indications of interest)

• Produce high quality and well documented data with strong attention to detail

• Fostering scientific excellence, open scientific exchange, and deep scientific rigor

• Present experimental results at both internal and external meetings

• Author and edit scientific manuscripts

Qualifications:

• Ph.D. in Molecular/Cell Biology, Biology, Biochemistry or related field with 3-5 years of industry experience in antibody or small molecule drug discovery and/or radiopharmaceuticals

• Experience in Oncology and preclinical drug development

• Hands-on experience in drug screening and candidate drug selection

• Proven team leadership experience managing and/or supervising junior scientists

• Strong background in development and technical execution of in vitro assays, including development, optimization and data interpretation.

• Experience with development and validation of in vivo cancer models and efficacy studies in small rodents

• Demonstrated ability to adapt to, perform, and develop unfamiliar methods in a rapidly evolving research environment

• Demonstrated success in generation of actionable data to inform a go/no-decision point within a project/program

• Experience with the safe handling of radioactive and biohazardous materials is an asset

• Ability to work effectively in a multi-disciplinary team

• Excellent communication skills and ability to communicate with colleagues at all levels

Fusion Pharmaceuticals is an equal opportunity employer that is committed to inclusive, barrier-free recruitment and selection processes, if contacted for an interview, please advise Human Resources if you require accommodation.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.