Senior Scientist I, LC-MS/MS Small Molecule In Vitro/In Vivo Bioanalysis

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Job Description

The Non-Regulated Bioanalysis group in the Quantitative, Translational & ADME Sciences Department at AbbVie has an open position for a Senior Scientist I position in North Chicago, IL to perform small molecule and peptide bioanalysis supporting drug discovery and development. The successful candidate will be responsible for independently conducting quantitative LC-MS/MS bioanalysis in support of in-vivo PK/PD/TK studies, along with providing insight and answering technologic or key scientific questions to collaborators and junior scientists.

Responsibilities:

• Perform quantitative LC-MS/MS analysis of small molecules and peptides to provide bioanalytical support for PK/PD, efficacy, and exploratory toxicology studies meeting customer satisfaction and project timelines.
• Routinely operate LC-MS/MS instrumentation, including maintenance, troubleshooting, identification and resolution of instrument and assay problems.
• Investigate, evaluate, and implement new methodologies, platforms, and technologies to meet challenging assay requirements and throughput while maintaining effective resource utilization.
• Serve as scientific interface and close partner to other teams for bioanalysis support and development/operationalization of novel assays.
• Maintain electronic laboratory notebooks (ELN) and manage study documentation in the Laboratory Information Management System (LIMS).
• Write or contribute to study reports for regulatory submissions.

Qualifications

• PhD (0-4 years), M.S. (8+ years) or BS (10+ years) in analytical chemistry or related field with relevant academic or industry experience.
• Strong LC-MS/MS method development background with direct experience in bioanalysis/assays and understanding of both experimental design and analytical practices required.
• Expertise with current high-throughput LC-MS/MS platforms (e.g., Leap autosamplers, Sciex API-6500/7500 triple quadrupoles), software (e.g., Sciex Analyst and/or OS, Electronic notebooks, LIMS, Discovery Quant) and automated sample preparation (e.g., Hamilton, Tecan Dispenser) platforms.
• Working experience in regulated bioanalysis and/or CRO/University Core facility settings will be a plus.
• Excellent personal, verbal, and written communication skills.
• Highly organized with keen attention to detail, enabling effective independent work and success within a matrix team environment.
• Desire to excel in a fast-paced environment, with strong problem-solving skills, and the ability to prioritize tasks and meet deadlines effectively.

Key Leadership Competencies:

• Build strong relationships with peers and cross functionally with partners outside of the immediate team to enable higher performance, proven ability to collaborate successfully across other groups within R&D.
• Creates a learning environment, open to suggestions and experiments to drive science in the field of interest.
• Embraces the ideas of others, nurtures innovation and manages innovation to reality, learns fast, grasps the "essence" and can change course quickly when needed.
• Raises the bar and is never satisfied with the status quo.
• Highly motivated and self-driven with the flexibility to quickly adapt to different projects.

Additional Information

Applicable only to applicants