Sr /Principal Scientist CNS Drug Discovery

Senior Scientist/Principal Scientist CNS Drug Delivery

Job Summary:
Our client is a cutting-edge neuroscience company developing innovative brain shuttle technology aimed at revolutionizing the delivery of drugs and molecules to the brain. This proprietary platform is designed to overcome the blood-brain barrier and provide groundbreaking solutions for treating Alzheimers disease, neurodegenerative disorders, and psychiatric conditions. As a well-funded biotech firm, they offer a unique opportunity to join a highly dynamic team dedicated to advancing CNS drug delivery technologies. We are seeking a Senior Scientist/Principal Scientist to lead bioanalytical and biodistribution studies, manage IND-enabling efforts, and contribute to the development of this novel brain shuttle platform.

Job Specifications:

• Job Type: Full-time
  
• Company: Leading Neuroscience Biotech Company
  
• Location: Thousand Oaks
  
• Pay Rate: $160,000 annually (flexible for highly experienced candidates)
  
• Shift: Day Shift

Roles and Responsibilities:

• Lead and execute bioanalytical and biodistribution studies to advance CNS drug delivery platforms.
  
• Develop and validate assays for quantifying drug levels in plasma, brain, and other tissues.
  
• Design and interpret Pharmacokinetic/Pharmacodynamic (PK/PD) studies to evaluate drug delivery, efficacy, and safety.
  
• Manage IND-enabling studies, collaborating closely with internal teams and external CRO partners to ensure timely execution and compliance.
  
• Mentor and guide junior scientists, fostering a collaborative and innovative research environment.
  
• Stay abreast of the latest scientific advances in CNS drug delivery, bioanalysis, and regulatory frameworks to ensure research practices are aligned with industry standards.

Qualifications & Skills:

• Education: PhD in a life sciences field (e.g., Neuroscience, Pharmacology, Biology) or related discipline.
  
• Experience: 8-10+ years of industry experience in bioanalytics, biodistribution, and PK/PD studies, ideally with large molecules (antibodies, oligonucleotides, peptides). CNS-related experience is highly preferred.
  
• Proven track record of managing IND-enabling studies and working effectively with CROs.
  
• Expertise in blood-brain barrier biology and CNS drug delivery technologies.
  
• Strong background in bioanalytical methods, including ELISA, RT-qPCR, and histology.
  
• Excellent problem-solving skills, scientific rigor, and the ability to thrive in a fast-paced, dynamic research environment.
  
• Experience in managing and mentoring scientific teams, with a focus on study design and execution rather than performance reviews.

Opportunities:

• Lead pioneering research in CNS drug delivery, contributing to the development of transformative therapeutics for neurodegenerative and psychiatric disorders.
  
• Collaborate with a talented and driven team of scientists to push the boundaries of biotechnology and neuroscience.
  
• Potential for career advancement within a rapidly growing, well-funded biotech company at the forefront of drug delivery innovation.

Company Culture:
Join a dynamic, passionate team at a cutting-edge neuroscience company where creativity, collaboration, and scientific excellence drive our mission. Our supportive work environment empowers team members to explore new ideas, grow professionally, and contribute to making a lasting impact on healthcare solutions for neurodegenerative diseases.

9846848