Scientist I, NGS

About us:

Ascidian is redefining the treatment of disease by rewriting RNA.

Ascidian Therapeutics was founded to rewrite RNA by editing and replacing human exons. We were inspired by ocean creatures, called Ascidians, who are primordial ancestors of vertebrates. To grow from larvae to adults, ascidians re-engineer their transcriptome through RNA editing via trans-splicing and alternative splicing.

In our Brighton/Boston labs, RNA biology meets today's cutting-edge genomics, computational biology, and deep-sequencing technologies to create a new class of medicines that address the underlying causes of disease. We welcome you to come join our vibrant team and help us lead the way into a new gene therapy era.

Scientist I, NGS

Ascidian Therapeutics is seeking a Scientist I with NGS and molecular biology experience to join our team. The candidate will work both independently and as part of a collaborative team to generate data from various genomics-oriented workflows and assist in optimizing and validating new technologies and procedures. The ideal candidate must be creative, detail-oriented, have excellent communication skills, and be willing to work in a dynamic entrepreneurial environment.

Job Responsibilities:

• Prepare and sequence a range of NGS library types to support discovery efforts
• Develop and optimize custom NGS assays (short read and long read)
• Maintain cell cultures and conduct cellular assays
• Work independently and collaboratively with multi-disciplinary teams to solve complex problems
• Maintain detailed records using ELN
• Collaborate and communicate across a diverse research team to progress scientific goals
• Support the creation and expansion of the company's intellectual property
• Help create an entrepreneurial and creative culture that will deliver transformational therapies to patients

Qualifications:

• BS/MS in molecular/cellular biology, biochemistry, or related field
• 5+ years relevant laboratory experience in an academic or biopharmaceutical setting
• Extensive experience in NGS library preparation and instrumental operation
• Molecular cloning (e.g., traditional, Golden Gate, Gibson, etc.)
• Protein biochemistry and enzyme activity assays (Extraction, Western blot, etc.)
• Experience in RNA/DNA processing, qPCR, and RT-PCR/ddPCR
• Detail-oriented, well organized, and dependable record keeping
• Highly motivated team member with excellent communication skills
• Demonstrated problem-solving and troubleshooting skills
• Experience in NGS data analysis is a plus

Benefits:

We provide a vibrant startup environment where every employee contributes to our culture and science. We offer a generous total rewards plan that includes competitive compensation, stock options, and benefits. Our benefits include a top-tier health and wellness plan, commuter reimbursement or paid monthly parking, tuition or loan reimbursement, career development opportunities and so much more.

A final note - we highly encourage you to apply for our position, even if you are not sure you meet all the requirements. Everyone has unique talents, and at Ascidian, we look not only at your experience but your potential. We know that the best teams consist of diverse backgrounds, so please apply!