Postdoctoral Fellow Multimodal Omics & Neurodegeneration

Design your own scientific path at the Johns Hopkins University School of Medicine

Why join us?
Chart your trajectory. We give postdocs true intellectual ownership. In addition to predefined analyses, choose the questions you want to explore, develop your own grant proposals, and take firstauthor leadership on papers.
Unmatched data depth. You will work with one of the richest, multimodality resources in Alzheimers and aging including longitudinal plasma and CSF proteomics, neuroimaging, neuropathology and a recent expansion into singlecell transcriptomics and spatial proteomics, all linked to decadesdeep clinical cohorts (JHADRC, BIOCARD, BLSA).
Interdisciplinary ecosystem. Collaborate with neurologists, neuropathologists, neuropsychologists and neuroradiologists and with machinelearning and statistics experts across Hopkins.
Career development. Internal university (Discovery, Catalyst, KL2, and ADRC project) grants, and travel funds let you build the CV you need for either an independent academic lab or biotech/AI roles.

The project space:
We are integrating highthroughput proteomics with singlecell & spatial transcriptomics of immune cells (CSF, blood) and human brain tissue from the large JHU brain bank. Your mission: extract novel biomarker signatures and therapeutic targets that explain disease heterogeneity across the Alzheimers spectrum.
You can:
Lead denovo multiomic integration pipelines
Design your own subproject leveraging cuttingedge wetlab platforms (Olink Explore, DIA_MS, NULISA, Aviti24 cytoprofiling and tissue transcriptomics) available in the lab.
Publish firstauthor papers and present at ISMB, AAIC, ANA and others

What you will do:
Analyze largescale proteomic, singlecell, spatial datasets to discover pathwaylevel disease mechanisms.
Build reproducible pipelines in R/Python
Integrate proteomic signatures with neuroimaging, cognitive and neuropathology phenotypes.
Write manuscripts, contribute to grant proposals, and present findings at international conferences.

What you bring?
PhD (or near completion) in Bioinformatics, Computational Biology, Data Science, Statistical Genomics, or related field.
Proficiency in R and Python; comfortable on Linux clusters. Bonus points for Julia or cloudnative workflows.
Proven analytical reasoningable to translate numbers into biological insight.
Desire to innovate independently while thriving in a collaborative, multidisciplinary team.

Career development advantages at JHU:
Internal KL2 and Catalyst awards reserved for earlycareer investigators.
Access to Hopkins Postdoc Association workshops on grantsmanship, leadership & science communication.

Location & resources:
Dr. Moghekars BrainSignatures Lab is housed on the Bayview Campus of Johns Hopkins University (Baltimore, MD) with newly renovated wetlab and computational suites. Visit us:
This fulltime position comes with the comprehensive Johns Hopkins postdoctoral benefits packageincluding health, vision, dental, retirement contributions, free MTA transit pass, and subsidised childcare. Details:

How to apply:
Submit a single PDF containing (1) your CV, (2) a statement of research interests & career goals (cover letter), and (3) contact information for three references