Senior Research Associate, Ex-Vivo Biology / Pharmacology

About the Company:

Tentarix Biotherapeutics is a biotechnology company with a revolutionary platform for the discovery of next generation, multispecific biologic drugs, with the potential to make a significant difference in the lives of patients suffering with diseases, such as cancer and autoimmunity.

We are led by a seasoned executive team with proven expertise in the field of multispecific drug discovery, drug development, and company-building. We are supported by top tier healthcare investors and have several ongoing partnered programs with Gilead and AbbVie.

We are committed to hiring and retaining highly qualified and motivated team members who are passionate about making a difference for patients in the modern drug discovery landscape.

The Tentarix culture is founded on integrity, accountability, teamwork, and respect. Our team members are creative, hands-on, self-directed, and determined. We offer autonomy, flexibility, a modern culture, and the best tools to ensure the success of our team.

Role:

The Senior Research Associate will lead the execution of in vitro, ex vivo, and in vivo studies to assess the efficacy of engineered protein therapeutics across various Immuno-Oncology and Autoimmune disease models. The primary focus will be on performing multi-color flow cytometry for immune profiling and signaling analysis, as well as conducting RT-PCR for mRNA transcriptome analysis on diverse samples from vivo models or primary cells. Additional responsibilities include supporting vivo studies to evaluate disease models and assessing the pharmacokinetics and pharmacodynamics of biotherapeutics.

Responsibilities:

• Perform multi-color flow cytometry for immune profiling and signaling analysis, along with RT-PCR for mRNA transcriptome analysis on samples from vivo models or primary cells.
• Contribute to various in vitro assays, including MSD, ELISAs, cell-based biological assays, and immune cell bioassays.
• Support the execution of pharmacology studies, including immune cell bioassays, PK/PD assays, and disease models for Immuno-Oncology and Autoimmune diseases.
• Design and conduct experiments independently, analyze data, and present findings in group meetings.
• Maintain detailed and accurate records of protocols, data, and results.

Qualifications and Skills:

• M.S/B.S./B.A. with 2-6+ years of industry experience in the field of immuno-oncology, immunology, or autoimmune diseases.
• Extensive experience in multi-color flow cytometry for immune profiling and immunology bioassays is essential.
• Demonstrated expertise in performing RT-PCR techniques for mRNA transcriptome analysis using samples from in vivo models and/or primary cell cultures. Knowledge of single-cell RNA sequencing methodologies is considered a valuable bonus.
• Technical experience in execution of ELISAs, and MSD, is a plus but not required.
• Experience with animal handling and basic in vivo procedures of dosing, such as injections with various routes (s.c., i.p., i.v.), bleeding (tail bleed, cheek bleed, Retro Orbital), tumor measurement and collection of various organs for necroscopy for toxicology studies is preferred
• Experience with Oncology, immune-oncology or autoimmune disease models is also preferred
• Experience with cell culture including the culture of immune cells and tumor cells is desired
• Thrive in a cross functional team environment and committed positively contributing to Tentarix's supportive small company culture
• Trustworthy with highest integrity, committed to ethical and scientific standards.
• Excellent verbal and written communication skills

The wage range for this role takes into account the wide range of factors that are considered in making compensation decisions including, but not limited to, skill sets, experience, training, licensure, certifications, and other business and organizational needs. The disclosed range estimate has not been adjusted for the applicable geographic differential associated with the location at which the position may be filled. At Tentarix, it is not typical for an individual to be hired at or near the top of the range for their role and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current range is $88,000 - $105,000 + bonus target + benefits + equity.

Our employees are the Company's most valuable assets, so we offer attractive compensation and benefits packages to retain the best in the field. Tentarix is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Applicants must be currently authorized to work in the United States on a full-time basis.

Tentarix Biotherapeutics, Inc. also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. We are an E-Verify employer.