Associate Scientist, Global Biologics

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Job Description

OBJECTIVES/PURPOSE

D esign and implement exp eriments to screen for drug candidates and to address mechanisms -of-action of therapeutic molecules . Perform complex cell-based functional experiments independently . Act as a subject matter expert (SME) for d rug discovery in the Cell therapy and Immuno - Oncology /Immuno-Therapy .

A CCOUNTABILITIES

• Provide broad assay development support for early-stage drug discovery projects in disease area s of the Cell therapy

• Design, execute, and validate a variety of assays to understand mechanisms of action and characterize CAR T

• Collaborate with automation engineers to identify suitable approaches to utilize laboratory automation for the execution of variable cell-based assays .

• CAR T generation (transduction and expansion) and functional evaluation of CAR expression, phenotyping, cytokine detection and killing potency in vitro.

• Spend ~ 85% of time in the laboratory to maintain and implement cell cell-based assay platform and perform experiment s

• I nterfac e with project teams to meet timelines for project progression

• Present research findings clearly and effectively at internal and external meetings

• Troubleshoot complex problems in creative and effective ways

• Ability to manage work flow to deliver quality results in a timely man ner

• Troubleshoot complex problems in creative and effective ways and actively participates in innovation and/or optimization of established processes to ensure data relavence and quality

• Ability to make data-driven influence s on project decision-making

EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS :

• Master's degree in cell immunology , protein / antibody science, and/or > 3 years equivalent relevant work experience with strong knowledge of T/NK cell biology , immuno-oncology , and cell therapy. Bachelors degree with >6 years relevant experience .

• Tissue culture, including application of aseptic techniques for media compounding , passaging , maintenance, and cryopreservation of cell cultures .

• Experience with immune cell (T/NK cells ) isolation , culture, and engineering.

• Proficiency in immune cell phenotyping ( surface / intracellular ), cytokine detection (multi-color flow cytometry , Luminex , MSD ), cytotoxicity assay (short or long term killing ) , internalization assay and High content imaging (Opera Phenix ) or other functional assays .

• Proficient in data generation ( Prism , Excel ), presentation, and troubleshooting .

• Experience with viral delivery methods is a plus.

• Knowledgeable and experienced in cell biology and antibody characterization

• E xperience in troubleshooting , assay optimization and data quality control is a plus

• Skilled in data analysis , interpretation , and data reporting

• Hands-on cell-based functional assay experience

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Boston, MA

U.S. Base Salary Range:

$99,500.00 - $156,420.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained , certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based e mployee s may be eligible for s hort - t erm and/ or l ong- t erm incentive s . U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations Boston, MA Worker Type Employee Worker Sub-Type Regular Time Type Full time

Job Exempt

YesIt is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.