Scientist - Materials Engineering & Crystallization

Working with Us
Challenging. Meaningful. Life-changing. Those arent words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. Youll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .

Drug Product Development (DPD)

Our Drug Product Development team is committed to CMC design, development, and commercialization of innovative drug products to improve patient lives. We leverage the best people, collaboration, and cutting-edge innovation to achieve this commitment. BMSs internal engine of innovation includes unrivaled industry leading expertise in CMC development of small molecules, protein biotherapeutics, protein degraders, and other therapeutic modalities. We collaborate closely with our colleagues in R&D and Commercial to design our drug products. Here, youll get the chance to grow and thrive through opportunities that are uncommon in scale and scope.

As a Scientist in the Drug Product Development - Materials Engineering and Crystallization (MEC) Group, the main responsibilities will be to develop crystallization processes and tailor the Active Pharmaceutical Ingredient (API) material characteristics to balance drug substance processability and drug product performance. The successful candidate will drive insight into how API particle properties impact the bioavailability and manufacturability of the drug product. At BMS, MEC engineers participate in multidisciplinary teams to drive development of novel medicines and deliver scalable, robust processes for drug substance and drug product. The candidate is expected to have exposure to crystallization fundamentals and an ability to learn API crystallization process development.

Primary activities and responsibilities will include:

• Work in a multi-disciplinary team to ensure drug substance attributes are robustly controlled and satisfy the needs of the drug product

• Independently execute lab experiments and report contextualized results

• Phase-appropriate crystallization process development and troubleshooting

• Powder property assessments and particle engineering

• Salt and form control strategy development to support material selection and delivery of API quality attributes

• Basic solid state material characterization

It is expected that the candidate will work with a broad range of materials, such as crystalline and non-crystalline APIs including small molecules, peptides, oligonucelotides as well as drug product intermediates that will be used in the design of robust oral and injectable drug product formulations. Experience in laboratory experimentation is expected and experience with independent laboratory development of crystallizations is preferred. Familiarity with solid state characterization techniques such as particle size measurement, polarized light microscopy, XRD, BET, TGA, and DSC is desired. In addition, an understanding of process analytical techniques (Raman, FBRM, EasyViewer, Blaze, ATR-FTIR, NIR) and their application to crystallization process development is desired. Experience with process modeling, molecular simulation, machine learning, or data visualization is desired.

Requirements :

• Ph.D. in Chemical Engineering or related field with 02 years of industry experience; or M.S. with 24 years of experience; or B.S. with 57 years of experience

• Fundamental understanding of thermodynamics, kinetics, and transport phenomena.

• Excellent problem-solving skills.

• Outstanding oral and written communication skills.

• Demonstrated ability to identify and solve problems through independently designed and executed experiments.

• Experience in polymorph control, particle engineering, and process scale up is highly desired.

At BMS, MEC scientists collaborate across drug substance, drug product and analytical development teams. This position requires employees to work safely at laboratory and pilot plant scale with chemical agents which may pose health or safety hazards if improperly handled. We are looking for an energetic and engaged scientist that can work collaboratively and has passion to deliver novel medicines to patients.

If you come across a role that intrigues you but doesnt perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as Transforming patients lives through science , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ eeo -accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

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