Sr. Principal Scientist, DMPK

Who We Are:

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs.

What We Do:

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit neurocrine.com , and follow the company on LinkedIn , X and Facebook . ( *in collaboration with AbbVie )

About the Role:

Contributes to long-term strategy and create operational plans to enable the growth and enhance productivity of the DMPK group. Oversees novel and creative methods to solve sophisticated, highly complex problems. Provides leadership and direction for assigned functions related to Drug Metabolism and Pharmacokinetics (DMPK) discovery and development support. Act as primary point of contact for DMPK scientific efforts and serve as a DMPK expert for leadership and team briefings. Provided leadership to, mentorship to and frequently supervise the day-to-day work of less experienced team members.

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Your Contributions (include, but are not limited to):

• Contributes to the DMPK long-term strategy planning and leads the development of strategic project / group goals and methods

• Oversees both projects and teams for in-vivo and in-vitro drug metabolism studies, PK/TK/PD studies, and/or drug permeability and transport studies

• Conceptualize, identify, develop novel strategies leading to developing and implementing methodologies to characterize DMPK properties of drug candidates

• Provides recommendations on behalf of DMPK when needed.

• Selects, on-boards, and oversees outsourcing partners of DMPK studies, oversees testing / troubleshooting all data, results and provides recommendations to solve technical issues, ensures partners adhere to contractual obligations and standards, within budget

• Provides expert level contribution in the preparation and review of regulatory submissions

• Will provide leadership and mentorship to and frequently manage the day-to-day work the team

• Performs other duties as assigned

Requirements:

• BS/BA in biology, chemistry, or related science field and 15+ years of experience acting as a DMPK representative on discovery teams. Significant experience in an ADME laboratory is required

• MS/MA in biology, chemistry, or related science field and 13+ years of similar experience noted above OR

• PhD or equivalent and 7+ years of relevant experience; may include postdoc experience

• Extensive theoretical and hands-on experience with multiple technologies and methodologies such as: automation, tissue culture, LC-MS/MS, radioisotope use, PK analysis and modeling and simulation software

• Individual will have authoritative knowledge in at least one DMPK core competency and expert knowledge in multiple DMPK core competencies (instrumental analysis and automation, enzymology and cell culture, biotransformation, PK/PD modeling and analysis).

• Seen as a company expert on scientific principles, methods and techniques

• Stays abreast of the latest technology and recommends new laboratory instrumentation and/or PK analysis and/or modeling and simulation software

• Expertise acting as a DMPK representative on all assigned teams

• Applies understanding of the team's place in the larger organization, and discusses changes, progress, and issues as they relate to other areas

• Maintains substantial knowledge of principles and theories and acts as a technical lead on various projects

• Leads the development of intellectual property

• May utilize working knowledge of other related disciplines to provide solutions to a wide range of difficult problems

• Ability to work as part of and lead multiple teams

• Good leadership, mentoring skills and abilities typically leads lower levels and/or indirect teams

• Excellent communications, problem-solving, analytical thinking skills

• Sees broader picture and longer-term impact on division/company.

• Ability to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiency

• Excellent project management, strong project leadership skills

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Neurocrine Biosciences is an EEO/Disability/Vets employer.

We are committed to building a workplace of belonging, respect, and empowerment , and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications dont line up to exactly what we have outlined in the job description.

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The annual base salary we reasonably expect to pay is $153,800.00-$222,850.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 30% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.