Sr. Research Scientist, Toxicology

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.

The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.

Job Summary (Primary function)
This position is responsible for providing support in Histology, Clinical Pathology and Necropsy to Toxicology, Translational Medicine, IAI, Biotherapeutics and Preclinical Pharmacology.

Essential Functions of the Job (Key responsibilities)

• Perform necropsy of mice and rats, oversee necropsy setup, cutting, and trimming. Utilize knowledge of Pathology Data Systems (PDS) to enter macroscopic findings and organ weights.
• Clinical Pathology setup and instrument maintenance per study. Collection and running of Hematology and Clinical Chemistry samples using the current in-house equipment. Working knowledge of analyte ranges, interpretation of data, control data and calibration data. Use of PDS to transfer Clinical Pathology data and QC of said data.
• Preparation of Histology slides from various animal models in collaboration with CRO's and in-house study tissues, including trimming, processing, embedding, sectioning, and H&E staining. Assist with quality assessment of the Pathology slides. Working knowledge of maintenance of the instrumentation to perform these functions.
• Preparation of immunohistochemically stained tissues sections and organic stained tissue sections on a per study basis.
• Archive gross tissues, tissue blocks, and slides generated by the Histology group. This includes maintaining current inventory and records of all archival material. This will also include coordinating the movement of blocks to EPL (as deemed necessary by Archivist) and managing the disposal of formalin-fixed tissue within timelines as determined by our pathologist.
• Receipt, inventory, and return of GLP and non-GLP peer review studies from CROs as outlined by our Peer Review SOP. Coordinate with Quality Assurance regarding our Biennial Review.
• Collaborate and support other groups in the method development of animal models, ensuring inclusive practices and diverse perspectives are considered. Working knowledge of cell culture preparation, alternative media preparation, and whole blood assays, with an openness to diverse methodologies and inclusive scientific approaches.
• Provide training and support to team members, as needed.

Qualifications (Minimal acceptable level of education, work experience, and competency)

• Bachelor's or Master's degree in Biology, Medical Technology, or a related field; or equivalent education and experience.
• ASCP HT Certification is preferred but not required, and equivalent experience or certifications will be considered.
• Relevant experience in the pharmaceutical industry is preferred, but not required, to encourage candidates with diverse backgrounds and experiences to apply.

Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.

Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.

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