Sr Research Associate 2, LC/MS in Center of Technology Excellence

Title: S enior Research Associate 2 , CoTe
Employee Type: FTE
Location: San Rafael, CA

S UMMARY

The Center of Technology (CoTe) is a centralized laboratory built around platform technologies and made available to scientists and physicians across Research and Development of BioMarin. The Mass Spectrometry (MS) Core within the CoTe provides collaboration , expert advice, service, training, and open access to state-of-the-art MS technolog ies to the entire scientific community of R&D . Our lab contains 15 mass spectrometers, including Orbitraps, QQQs, Q-Traps, and Q-TOFs (ESI + MALDI).

We are searching for a highly motivated and experienced biological mass spectrometrist to develop and implement LC/ MS-based bioanalytical assays and workflows that will accelerate drug discovery and development at BioMarin. This position offers a unique career opportunity to work on the entire spectrum of a product lifecycle, from early drug discovery and non-clinical work through all stages of clinical development, including post-marketing work. The successful candidate will collaborate directly with colleagues from the CoTe, Research , and Translational Sciences to explore a diverse range of disease areas and treatment modalities. This person will be in a position to apply LC/ MS-centric platforms to accelerate drug discovery and development, while maintaining a critical eye on assay quality and maintaining regulatory standards , when applicable .

RESPONSIBILITIES

• Develop analytical methods and workflows to quantify drug s , metabolites and biomarkers in various biological matrices. Techniques may include (but are not limited to) mass spectrometry , HPLC/UPLC, micro-flow LC and nano-flow LC .
• Provide scientific oversight for outsourced assay transfer and validation , participate in audits and inspections, and adhere to regulatory compliance standards , when applicable .
• Develop new workflows , or bring in new technology from the outside, to enhance the analytical capabilities of the MS Core or CoTe, more broadly .
• Clearly and thoroughly document your work in your electronic notebook (Benchling).
• Present results, conclusions, and implications to Research and Translation Sciences clients and early development teams .
• Provide guidance and mentorship to junior lab staff and provide training /support to open access users of the MS Core .
• Prepare SOPs and other documents such as assay development reports and data reports for testing results.
• Share responsibility for lab management and maintenance duties.
• Participate in scientific meetings and produce original peer-reviewed publications.

EDUCATION / EXPERIENCE

• A BS/MS with 8+ years of industry experience in biological mass spectrometry . Candidates with a Ph . D . in Biology, Chemistry or related field and a research emphasis on mass spect rometry applications plus 2+ years of industry experience using mass spectrometry and liquid chromatography in a bio analytical field are also encouraged to apply .
• Strong analytical background with proficiency in developing and optimizing quantitative LCMS assays is required
• Experience with automating sample preparation, data collection and processing would be advantageous
• Experience with GLP and/or GCP-compliance and regulatory filing is a plus
• Demonstrated ability to work in a fast-paced , team-oriented environment with aggressive timelines
• Ability to interact successfully with team members from a wide variety of functional areas and diverse expertise levels.
• Publication record supporting a consistent contribution to successfully completed projects