Research Associate II - Protein Expression and Purification

Join the forefront of groundbreaking research at City of Hope where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

The laboratory of Dr. Jeff Perry, Assistant Professor of Cancer Biology and Molecular Medicine at the City of Hope Medical Center, is seeking a highly motivated and detail-oriented Research Associate to join our dynamic research team. Our lab is dedicated to the discovery and development of novel small-molecule therapeutics for cancer and diabetes, with a strong emphasis on structural biology and biochemistry.

The Research Associate will primarily be responsible for protein expression and purification to support drug discovery efforts. Additional duties may include molecular cloning, biochemical assays, and crystallization screening.

The Perry lab Offers:

• A stimulating and supportive research environment at the cutting edge of biomedical research.
• Opportunities for professional development and scientific growth.

As a successful candidate, you will:

• Perform recombinant protein expression in bacterial systems.
• Execute protein purification techniques using affinity, ion-exchange, size-exclusion chromatography, and FPLC systems.
• Maintain accurate laboratory records and documentation.
• Assist with molecular cloning, PCR, plasmid preparation, and related techniques.
• Conduct biochemical assays to evaluate enzyme kinetics and ligand-binding interactions.
• Participate in crystallization trials and screening to support structural biology projects.
• Collaborate effectively with other lab members and communicate research findings in team meetings.

Your qualifications should include:

• Bachelor's degree. Master's degree preferred.
• Two years related research/ laboratory experience with a Bachelor's degree or one year related research/ laboratory experience with a Master's degree.

Preferred qualifications:

• Experience with molecular cloning techniques, such as PCR, ligation, and plasmid construction.
• Familiarity with biochemical assays, including enzyme activity assays, ELISA, and ligand-binding assays.
• Prior experience or exposure to protein crystallization methods.

Additional Information:

• Along with your application, interested candidates should submit a single PDF including a CV, a cover letter detailing relevant experience, and contact information of three references.

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

City of Hope is an equal opportunity employer.

To learn more about our Comprehensive Benefits, please CLICK HERE.