Postdoctoral Fellow

The Postdoctoral Fellow p rimary responsibility will be to conduct research into early molecular mechanisms underlying the development and progression of Alzheimers dementia (AD). Projects focused on inflammatory changes in the brain and blood-brain barrier dysfunction will be explored in specimens from human subjects with and without AD, as well as in rhesus macaques, in the context of normal aging and/or infectious disease. The position requires experience and training in performing various molecular biological techniques, including but not limited to total spatial transcriptomics, laser-capture microdissection, DNA/RNA isolation, real-time PCR, RNAseq, cloning, gel-electrophoresis, immunoprecipitation/western blotting, multi-color flow cytometry, histology and immunohistochemistry, and computational data analysis and interpretation.

REQUIRED EDUCATION AND EXPERIENCE:

1. Ph.D., D.V.M., and/or M.D. in a biological or medical science.

2 . Previous experience with molecular biological techniques, such as total DNA/RNA isolation and purification, plasmid extraction and purification, PCR including real-time PCR, cloning, gel-electrophoresis, immunoprecipitation/western blotting, and immunohistochemistry and non-biased steriologic quantification. Experience with multi-color flow cytometry staining/data analysis, immunoprecipitation/western blotting and image processing.

REQUIRED KNOWLEDGE, SKILLS, ABILITITIES/COMPETENCIES TYPICALLY NEEDED TO PERFORM THIS JOB SUCCESSFULLY:

1. Proficiency with common laboratory equipment and techniques.

2. Strong personal and communication (oral and written) skills.

3 . Knowledge of various software programs (including R, python, data presentation packages, spreadsheets and advanced word processing).

4 . Organizations skills.

5. Familiarity with computers (both Mac & PC).

6 . Direct experience with running and installing scientific equipment.