Senior Scientist, Protein Sciences

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Position Summary

We are seeking a highly motivated and innovative Senior Scientist to join the Discovery Biotherapeutics Department in San Diego. The ideal candidate will possess a demonstrated expertise in protein sciences with an emphasis on protein purification, process optimization, and characterization. Responsibilities will include a range of activities related to protein purification and characterization of complex antibodies. The ideal candidate will be proficient in the design, optimization, and execution of multi-step purification, analytical data interpretation, troubleshooting and formulation of final product, while maintaining a highly productive and collaborative culture.

Responsibilities

• Manage purification lab as a subject matter expert in purification and downstream processing.

• Prioritize/support the workload and troubleshoot complex purifications.

• Strategize lab operations, train junior members of staff, and coordinate activities with expression.

• Represent Protein Sciences across multiple program teams as part of the core team.

• Interface with key stakeholders on protein deliverables and timelines.

• Demonstrate a track record of initiative, creativity, organization, and independent performance at a high level combined with attention to detail and adherence to timelines/deliverables, and documentation.

• Participate on project teams to discover, optimize, and manufacture antibody-based biologics, and should be highly effective in collaborating with internal and external team members and CROs.

• Special emphasis will be placed on automated antibody purification, which will involve working with Cytiva AKTA (Pure/Avant) and Unicorn software.

• The candidate will show an independent ability to design purification methods, understand biochemical concepts and interpret data to generate and improve design.

• Mono and bispecific antibody purification: concentrating supernatants, preparation and packing of chromatography columns, and conducting endotoxin free chromatography, including operating preparative and analytical chromatography systems.

• Deep understanding of the principals of purification; CEIX, HIC, SEC, Affinity, Multi-modal, AEIX and how to apply them to complex antibody modalities.

• Perform in-depth analytical characterization of molecules: endotoxin measurements, protein quantitation assays, analytical HPLC chromatography (anHIC, anSEC), Capillary electrophoresis (CE-SDS and cIEF)

• Storing, inventorying, and ordering department supplies and chemicals and preparing chemical solutions according to department procedures, specifications, or supervisory instructions.

• Participate on cross-functional teams by performing assigned experiments and offering technical advice at team meetings; shares technical expertise with other colleagues; trains or provides guidance to other personnel, if needed.

• Maintain a neat, clean, and orderly work environment.

• Experience in external partnership management, due diligence for technology evaluation, project leadership and matrix management are a plus.

Basic Qualifications

• Bachelors Degree with 7+ years of academic or industry experience

or

• Masters Degree with 5+ years of academic or industry experience or

or

• PhD with 2+ years of academic or industry experience

Preferred Qualifications

Masters Degree with 5+ years of academic or industry experience in Bioengineering, Biochemistry, Molecular Biology or related discipline.

• Extensive hands with protein purification. Purification of other entities (viruses, antigens, nanoparticles is a plues).

• Antibody/protein analysis and characterization including, but not limited to SDS-PAGE, A280, CE-SDS, cIEF, AnSEC, AnHIC, Endotoxin.

• Exceptional organizational skills and attention to detail.

• Strong written and oral communication skills are essential.

• Excellent time management skills and multi-tasking capabilities.

• Automated liquid handling using the Lynx.

• Sample inventory management.

• Experience and knowledge of protein and antibody sequences, antibody databases and data management systems, and ELN.

• Bispecific antibody purification is desired.

• Must be very detail-oriented and organized, with excellent time-management and multitasking skills.

• Have outstanding analytic and problem-solving abilities.

• Display excellent verbal and written communication, interpersonal and presentation skills, as well as the ability to interact tactfully and effectively with employees at all levels of the organizational structure.

• Must be highly self-motivated, detail-oriented, well organized and work effectively as part of a team.

The starting compensation for this job is a range from $122,830 - $148,800 plus incentive cash and stock opportunities (based on eligibility).

The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit our BMS Careers Site .

Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Years holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.

If you come across a role that intrigues you but doesnt perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as Transforming patients lives through science , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ eeo -accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

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