Senior Principal Research Scientist/Director

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on X , Facebook , Instagram , YouTube , LinkedIn and Tik Tok .

Purpose:

The Senior Principal Research Scientist/Director of Drug Metabolism and Disposition (Biotransformation) will lead the biotransformation activities within the Drug Metabolism and Disposition department. This role aims to provide strategic direction, ensure high-quality data, and support the advancement of drug discovery and development through expert understanding of drug metabolism, pharmacokinetics, and biotransformation processes.

Responsibilities:

• Lead a team of scientists in designing and executing biotransformation studies, including both nonclinical and clinical studies.

• Develop and implement strategic plans for drug metabolism and biotransformation to support drug discovery and development projects.

• Serve as a subject matter expert to cross-functional teams, integrating in vitro and in vivo data for the understanding of absorption, distribution, metabolism, excretion (ADME), and pharmacokinetics.

• Ensure regulatory compliance for all studies and reports, providing oversight of radiolabeled and non-radiolabeled studies.

• Communicate findings and strategies clearly to project teams and management, both orally and through written reports.

• Collaborate with internal and external partners to ensure the timely and high-quality delivery of study data.

• Mentor and supervise junior scientists and laboratory staff, fostering an inclusive and empowering work environment.

• Contribute to scientific knowledge through conference presentations and publication of new research findings.

• Develop and maintain a research budget in alignment with organizational goals.

• Stay abreast of industry trends and advancements in drug metabolism and biotransformation methodologies.

Qualifications:

• Bachelors Degree in Science with 18 years of related work; Masters Degree Science or PharmD with 16 years of related work; PhD in Science or related field with 10 years of related work experience in drug metabolism and biotransformation.

• Demonstrated expertise in metabolite identification and ADME studies from discovery through IND/NDA submissions and regulatory interactions.

• Strong leadership, communication, and interpersonal skills.

• Experience with regulatory requirements for drug development.

• Deep understanding of ADME and PK/PD science, experience with both small molecules and biologics.

• Strong fundamental understanding of mass spectrometry and its strategic use for metabolite profiling and structural determination.

• Proficient in the use of advanced analytical techniques such as MS-Imaging and NMR

• Knowledge of developing role-based training plans and maintaining scientific rigor in training methodologies.

• Experience managing and mentoring teams within a dynamic research environment.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemay ultimatelypay more or less than the posted range. This range may be modified in thefuture.

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.

• This job is eligible to participate in our short-term incentiveprograms.

• This job is eligible to participate in our long-term incentiveprograms

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employee remains in the Company's sole andabsolutediscretion unless and until paid andmay be modified at the Companys sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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