Postdoctoral Fellow - Spector Lab New
- Cold Spring Harbor Laboratory
- Cold Spring Harbor, New York
- Full Time
Postdoctoral Fellow - Spector Lab
Salary
$74,300.00 Annually
Location
1 Bungtown Road, Cold Spring Harbor- Main Campus
Job Type
Full Time
Job Number
1698
Process Level
Scientific Laboratory
Department
Spector Laboratory
Opening Date
06/06/2025
DESCRIPTION
BENEFITS
Position Description
A postdoctoral position is currently available, in the laboratory of Dr. David L. Spector at Cold Spring Harbor Laboratory, for a highly motivated outstanding individual to study Long Non-Coding RNAs (lncRNAs) in Pluripotency and Differentiation. LncRNAs are an exciting class of of RNA molecules among which very few have thus far been functionally characterized in depth. We performed an RNA-seq screen in mouse embryonic stem cells and neural progenitor cells and identified differentially expressed lncRNAs. The proposed studies will build upon these findings and use innovative methods to interrogate the functional role of specific lncRNAs in pluripotency, differentiation, and disease. This knowledge will lead to new potential opportunities in regulating these processes to influence differentiation and impact reprogramming. Spector Lab
Selected publications:
Sunwoo,H., Dinger,M.E., Wilusz, J.E., Amaral, P.P., Mattick, J.S. and Spector, D.L. 2009. MEN e/b nuclear retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles. Genome Research 19, 347-359.
Bergmann, J.H. and Spector, D.L. 2014. Long non-coding RNAs: modulators of nuclear structure and function. Current Opinion in Cell Biology 26, 10-18.
Hazra, R., Brine, L., Garcia, L., Benz, B., Chirathivat, N., Shen, M.M., Wilkinson, J.E., Lyons, S.K., and Spector, D.L. 2022. Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment. Dev. Cell 57, 2450-2468.
Hazra, R. and Spector, D.L. 2022. Simultaneous visualization of long non-coding RNAs and proteins in whole-mount mouse preimplantation embryos using single-molecule fluorescence in situ hybridization and immunofluorescence microscopy. Front. Cell Dev. Biol. 10:986261. doi: 10.3389/fcell.2022.986261.
Position Requirements
Candidates must have (or soon receive) a PhD degree. Experience in mouse embryonic stem cell culturing and differentiation, genomic analysis, molecular biology, CRISPR-based approaches, and mouse models is a plus.
Supplemental Information
Salary
$74,300.00 Annually
Location
1 Bungtown Road, Cold Spring Harbor- Main Campus
Job Type
Full Time
Job Number
1698
Process Level
Scientific Laboratory
Department
Spector Laboratory
Opening Date
06/06/2025
DESCRIPTION
BENEFITS
Position Description
A postdoctoral position is currently available, in the laboratory of Dr. David L. Spector at Cold Spring Harbor Laboratory, for a highly motivated outstanding individual to study Long Non-Coding RNAs (lncRNAs) in Pluripotency and Differentiation. LncRNAs are an exciting class of of RNA molecules among which very few have thus far been functionally characterized in depth. We performed an RNA-seq screen in mouse embryonic stem cells and neural progenitor cells and identified differentially expressed lncRNAs. The proposed studies will build upon these findings and use innovative methods to interrogate the functional role of specific lncRNAs in pluripotency, differentiation, and disease. This knowledge will lead to new potential opportunities in regulating these processes to influence differentiation and impact reprogramming. Spector Lab
Selected publications:
Sunwoo,H., Dinger,M.E., Wilusz, J.E., Amaral, P.P., Mattick, J.S. and Spector, D.L. 2009. MEN e/b nuclear retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles. Genome Research 19, 347-359.
Bergmann, J.H. and Spector, D.L. 2014. Long non-coding RNAs: modulators of nuclear structure and function. Current Opinion in Cell Biology 26, 10-18.
Hazra, R., Brine, L., Garcia, L., Benz, B., Chirathivat, N., Shen, M.M., Wilkinson, J.E., Lyons, S.K., and Spector, D.L. 2022. Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment. Dev. Cell 57, 2450-2468.
Hazra, R. and Spector, D.L. 2022. Simultaneous visualization of long non-coding RNAs and proteins in whole-mount mouse preimplantation embryos using single-molecule fluorescence in situ hybridization and immunofluorescence microscopy. Front. Cell Dev. Biol. 10:986261. doi: 10.3389/fcell.2022.986261.
Position Requirements
Candidates must have (or soon receive) a PhD degree. Experience in mouse embryonic stem cell culturing and differentiation, genomic analysis, molecular biology, CRISPR-based approaches, and mouse models is a plus.
Supplemental Information
Job ID: 480418218
Originally Posted on: 6/8/2025
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