Immunogenicity Senior Principal Scientist

ROLE SUMMARY

The Immunogenicity Sciences Group within the Pharmacokinetics, Dynamics, and Metabolism (PDM) Department of Pfizers Preclinical & Translational Sciences is a dynamic industry-leading team whose mission is to identify key risks associated with unwanted clinical immunogenicity and influence drug design to mitigate those risks.

The Senior Principal Scientist, reporting to the Immunogenicity Sciences (ISci) Lead will play a pivotal role in the group. The role will have accountability for designing non-clinical immunogenicity risk assessment strategies for Pfizers biologics portfolio, overseeing their execution, and support ISci lab-based scientists in their critical role in delivering decision-making data within project timelines. For this, the role will collaborate closely with and key stakeholders across Pfizers Research and Development, including Protein Engineering, Clinical Pharmacology, Drug Safety, Pharmaceutical Sciences, and represent the group in cross-disciplinary activities and initiatives. As well, the role will drive the identification, development and deployment of innovative methods and approaches in support of non-clinical risk assessment and immunogenicity mitigation by design to contribute to the advancement of immunogenicity sciences. This unique opportunity will immerse the successful candidate in a diverse array of biotherapeutics modalities being designed and developed to meet patients needs across Oncology, Inflammation & Immunology, and Internal Medicine.

ROLE RESPONSIBILITIES

• Act as primary point of contact for all biologics portfolio project teams
• Design adequate immunogenicity de-risking strategies for biologics programs based on each program specificities
• Oversee execution of the strategies to deliver high quality decision-making data within project timelines
• Support ISci lab-based scientists in their pivotal role in data generation, analysis and interpretation
• Drive innovation through identification, development and deployment of state-of-the art technologies and approaches in support of non-clinical immunogenicity risk assessment
• Represent ISci in cross-disciplinary activities and initiatives
• Contribute to a change-agile, high performing culture of innovation, impact, accountability, mutual respect and trust in a fast-paced matrix environment

QUALIFICATIONS

Education and Technical Skills

• PhD with 6+ years of industry experience in drug discovery and development
• Core expertise & formal education in Immunology
• Recognized expertise in immunogenicity risk assessment of biologics
• Extensive practice of project management achieving results in a complex matrix environment
• Comprehensive hands-on experience with non-clinical immunogenicity risk assessment tools and analytical platforms
• Solid knowledge of state-of-the art in silico prediction models
• Understanding of opportunities and challenges related to translation of in vitro and in silico tools
• Significant knowledge of clinical immunogenicity monitoring and mitigation
• Direct experience in interacting with external organizations, including academics and CROs
• Track record of scientific achievement in the field of immunogenicity (publications, presentations)

Behavioral Competencies

• Innate drive to leverage a broad scientific curiosity to advance immunogenicity sciences
• Strong leadership in maintaining a high performing culture of impact and innovation, based on accountability, mutual respect and trust
• Ability to adjust and support team members success in a fast-paced, fast-changing environment
• Grow others; acknowledge contributions across the team
• High degree of self-awareness
• Safeguard diversity, equity and inclusion
• Demonstrate our values and behaviors of Excellence, Courage, Equity and Joy

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

PHYSICAL/MENTAL REQUIREMENTS

Ability to perform complex data analysis

Ability to rapidly synthesize complex and varied information

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

Occasional travel

Work Location Assignment: Hybrid

The annual base salary for this position ranges from $120,800.00 to $201,400.00. In addition, this position is eligible for participation in Pfizers Global Performance Plan with a bonus target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of lifes moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care providers name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

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