Scientist II/Sr Scientist, Cancer Biology

Company Overview

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted therapies designed to improve outcomes for cancer patients. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge targeted cancer therapies, including antibody-drug conjugate therapies (ADCs). Our most advanced pipeline programs are varegacestat (formerly AL102), a gamma secretase inhibitor which is currently in a Phase 3 trial for treatment of desmoid tumors; IM-1021, a ROR1-targeted ADC which is currently in a Phase 1 trial; and IM-3050, a FAP-targeted radioligand, which recently received IND clearance. Our pipeline also includes IM-1617, IM-1335, and IM-1340, all of which are preclinical ADCs pursuing undisclosed targets with expression in multiple solid tumors.

Position Overview

We are looking for a talented and passionate cancer biologist with experience developing and championing novel therapeutic concepts in a fast-paced and scientifically rigorous environment. The position will challenge you to leverage your deep understanding of cancer biology and pharmacology to engineer the next generation of targeted cancer therapeutics. In partnership with cross-functional teams across the company, you will lead the discovery, optimization, and nomination of new drug candidates for clinical development.

Key Responsibilities

• Apply extensive oncology knowledge to formulate new therapeutic concepts and guide their development.
• Make program-level decisions to enable deliverables, moving with urgency.
• Lead and manage preclinical programs from target selection to lead generation, optimization, candidate nomination, and IND submission.
• Design, execute, and analyze experiments to enable program decision making.
• Ensure seamless cross-functional integration with colleagues in antibody discovery, chemistry, translational sciences, program management, CMC, and clinical development and represent the biology perspective in discussions with other functional areas.
• Stay abreast of the latest scientific developments and trends in targeted therapies and integrate relevant advancements into program strategies.
• Contribute to patent filings, publications and external presentations.
• Contribute to the preparation and review of regulatory documents, including IND submissions, ensuring compliance with regulatory requirements.

Qualifications

• Ph.D. in Cell Biology, Cancer Biology, Bioengineering, Immunology, or related field.
• A minimum of 2 years of experience in biotech/pharmaceutical industry, with a focus on preclinical drug development in immunology or oncology.
• Experienced with cell based assays and working with biologics (antibodies, antibody like formats, ADCs, SCFEs, bi-specifics, etc).
• Oncology experience is required.

Knowledge and Skills

• Track record of contributing to the advancement of pre-IND programs and regulatory submissions is strongly preferred.
• Excellent leadership and communication skills, with the ability to collaborate effectively in a team-oriented environment. Experience leading cross-functional teams is strongly preferred.
• Experience working with antibodies and antibody-based therapeutics is preferred.
• Experience developing new therapeutic technologies is preferred.
• Previous management or mentoring experience is a plus.

WA State Pay Range - Scientist II: $129,625 - $155,443

WA State Pay Range - Senior Scientist: $139,741 - $173,888

Washington State Pay Range

$129,625 - $173,888 USD

E/E/O

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

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