Staff Scientist California Institute of Technology

Staff Scientist

Caltech

Job Category: Fulltime Temporary
Exempt Overtime Eligible: Exempt
Benefits Eligible: Benefit Based

Caltech is a world-renowned science and engineering institute that marshals some of the world's brightest minds and most innovative tools to address fundamental scientific questions. We thrive on finding and cultivating talented people who are passionate about what they do. Join us and be a part of the diverse Caltech community.

Job Summary

The Staff Scientist in the Reisman Lab will design and synthesize bifunctional molecules for targeted therapeutic delivery across the blood-brain barrier. These molecules combine a receptor-binding motif, modular linkers, and conjugation handles for attachment to therapeutic cargos. Efforts will focus on structure-activity relationship studies, linker diversification, and the development of new architectures to expand platform capabilities.

Essential Job Duties

• Design and synthesis of small molecules
• Characterization and Quality Control
  • Use NMR, LC/MS, and HPLC to characterize intermediates and final compounds.
  • Ensure purity, identity, and stability of synthesized molecules.
• Prepare reports and presentations summarizing synthetic progress, challenges, and proposed solutions.
• Participate in regular project update meetings.

Basic Qualifications

• Ph.D. in Chemistry.
• Post Ph.D. experience in an academic setting.
• Understanding of functional group compatibility and linker design.
• Experience with designing and synthesizing small molecules for biological targets.

Required Documents

• Resume.

To be considered for this position please visit our web site and apply on line at the following link:

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.

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