Principal Scientist, Translational PK/PD
- J&J Family of Companies
- Spring House, Pennsylvania
- Full Time
At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at
**Job Function:**
Discovery & Pre-Clinical/Clinical Development
**Job Sub** **Function:**
Pharmacokinetics & Pharmacometrics
**Job Category:**
Scientific/Technology
**All Job Posting Locations:**
La Jolla, California, United States of America, Spring House, Pennsylvania, United States of America
**Job Description:**
**About Innovative Medicine**
Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
Learn more at
**We are searching for the best talent for a Principal Scientist, Translational PK/PD** **to be located in Spring House, PA or La Jolla, California.**
**Purpose:** We are looking for a Pharmacokinetics Project Leader to join our Translational Pharmacokinetics, Pharmacodynamics and Investigational Toxicology (TPPIT) group, part of Preclinical Sciences and Translational Safety (PSTS) organization. The successful candidate will assume a leading role in driving Non-Clinical PK, ADME and PK/PD strategy and execution to enable timely recommendations for discovery programs, drive preclinical development through IND/CTA filing, and support non-clinical and translational PK deliverables for clinical programs.
**You will be responsible for:**
+ Apply relevant pharmacokinetics (PK) principles, drive relevant experiment and modeling strategy, and integrate PK/ADME/PD data with pharmacology and toxicology profiles to effectively inform program strategy and decisions.
+ Develop a deep understanding of the program biology/pharmacology and be an active partner on project teams, providing scientific leadership in the design and analysis of key experiments.
+ Work closely with cross-functional teams, providing technical direction in supporting program decisions, compound development plans, and regulatory submissions.
+ Author relevant sections of internal and regulatory submission documents and reports.
+ Engage our global TPPIT and PSTS functional areas to ensure the best science is used to support programs.
+ Work across multiple therapeutic areas and modalities (cell, proteins, ADCs, peptides, small molecules and RNA), and represent the program and TPPIT function at project review, portfolio governance and in Health Authority interactions.
**Qualifications:**
**Education:**
+ Minimum of a Bachelors Degree is required.
Skills/Experience:
+ Minimum of 6 years of relevant pharmaceutical experience is required.
+ Strong understanding of PK, ADME and PK/PD, with a track record of scientific achievements and project influence is required.
+ Ability to translate data into project relevance, as part of anticipating and mitigating program challenges is required.
+ Experience with quantitative modeling in describing preclinical and/or clinical PK/PD is required.
+ Excellent interpersonal, organizational, oral/written communication and teamwork skills are required.
+ Experience in drug development, including writing of DMPK sections for regulatory documents (e.g., IND/CTA/IB etc) would be preferred.
+ Prior experience in novel biologics modalities is preferred.
The expected pay range for this position is $115,000 to $197,800.
The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporations performance over a calendar/ performance year. Bonuses are awarded at the Companys discretion on an individual basis.
Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.
Employees may be eligible to participate in the Companys consolidated retirement plan (pension) and savings plan (401(k)).
Employees are eligible for the following time off benefits:
+ Vacation - up to 120 hours per calendar year
+ Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington - up to 56 hours per calendar year
+ Holiday pay, including Floating Holidays - up to 13 days per calendar year
+ Work, Personal and Family Time - up to 40 hours per calendar year
For additional general information on company benefits, please go to:
The compensation and benefits information set forth in this posting applies to candidates hired in the United States.
Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market.
This job posting is anticipated to close on June 20, 2025. The Company may however extend this time-period, in which case the posting will remain available on to accept additional applications.
Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.
Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (...) or contact AskGS to be directed to your accommodation resource.
\#LI-Hybrid
**The anticipated base pay range for this position is :**
$115,000 - $197,800
Additional Description for Pay Transparency:
The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporations performance over a calendar/performance year. Bonuses are awarded at the Companys discretion on an individual basis. Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance. Employees may be eligible to participate in the Companys consolidated retirement plan (pension) and savings plan (401(k)). This position is eligible to participate in the Companys long-term incentive program. Employees are eligible for the following time off benefits: Vacation up to 120 hours per calendar year Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington up to 56 hours per calendar year Holiday pay, including Floating Holidays up to 13 days per calendar year of Work, Personal and Family Time - up to 40 hours per calendar year Additional information can be found through the link below. The compensation and benefits information set forth in this posting applies to candidates hired in the United States. Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market.
**Job Function:**
Discovery & Pre-Clinical/Clinical Development
**Job Sub** **Function:**
Pharmacokinetics & Pharmacometrics
**Job Category:**
Scientific/Technology
**All Job Posting Locations:**
La Jolla, California, United States of America, Spring House, Pennsylvania, United States of America
**Job Description:**
**About Innovative Medicine**
Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
Learn more at
**We are searching for the best talent for a Principal Scientist, Translational PK/PD** **to be located in Spring House, PA or La Jolla, California.**
**Purpose:** We are looking for a Pharmacokinetics Project Leader to join our Translational Pharmacokinetics, Pharmacodynamics and Investigational Toxicology (TPPIT) group, part of Preclinical Sciences and Translational Safety (PSTS) organization. The successful candidate will assume a leading role in driving Non-Clinical PK, ADME and PK/PD strategy and execution to enable timely recommendations for discovery programs, drive preclinical development through IND/CTA filing, and support non-clinical and translational PK deliverables for clinical programs.
**You will be responsible for:**
+ Apply relevant pharmacokinetics (PK) principles, drive relevant experiment and modeling strategy, and integrate PK/ADME/PD data with pharmacology and toxicology profiles to effectively inform program strategy and decisions.
+ Develop a deep understanding of the program biology/pharmacology and be an active partner on project teams, providing scientific leadership in the design and analysis of key experiments.
+ Work closely with cross-functional teams, providing technical direction in supporting program decisions, compound development plans, and regulatory submissions.
+ Author relevant sections of internal and regulatory submission documents and reports.
+ Engage our global TPPIT and PSTS functional areas to ensure the best science is used to support programs.
+ Work across multiple therapeutic areas and modalities (cell, proteins, ADCs, peptides, small molecules and RNA), and represent the program and TPPIT function at project review, portfolio governance and in Health Authority interactions.
**Qualifications:**
**Education:**
+ Minimum of a Bachelors Degree is required.
Skills/Experience:
+ Minimum of 6 years of relevant pharmaceutical experience is required.
+ Strong understanding of PK, ADME and PK/PD, with a track record of scientific achievements and project influence is required.
+ Ability to translate data into project relevance, as part of anticipating and mitigating program challenges is required.
+ Experience with quantitative modeling in describing preclinical and/or clinical PK/PD is required.
+ Excellent interpersonal, organizational, oral/written communication and teamwork skills are required.
+ Experience in drug development, including writing of DMPK sections for regulatory documents (e.g., IND/CTA/IB etc) would be preferred.
+ Prior experience in novel biologics modalities is preferred.
The expected pay range for this position is $115,000 to $197,800.
The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporations performance over a calendar/ performance year. Bonuses are awarded at the Companys discretion on an individual basis.
Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.
Employees may be eligible to participate in the Companys consolidated retirement plan (pension) and savings plan (401(k)).
Employees are eligible for the following time off benefits:
+ Vacation - up to 120 hours per calendar year
+ Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington - up to 56 hours per calendar year
+ Holiday pay, including Floating Holidays - up to 13 days per calendar year
+ Work, Personal and Family Time - up to 40 hours per calendar year
For additional general information on company benefits, please go to:
The compensation and benefits information set forth in this posting applies to candidates hired in the United States.
Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market.
This job posting is anticipated to close on June 20, 2025. The Company may however extend this time-period, in which case the posting will remain available on to accept additional applications.
Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.
Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (...) or contact AskGS to be directed to your accommodation resource.
\#LI-Hybrid
**The anticipated base pay range for this position is :**
$115,000 - $197,800
Additional Description for Pay Transparency:
The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporations performance over a calendar/performance year. Bonuses are awarded at the Companys discretion on an individual basis. Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance. Employees may be eligible to participate in the Companys consolidated retirement plan (pension) and savings plan (401(k)). This position is eligible to participate in the Companys long-term incentive program. Employees are eligible for the following time off benefits: Vacation up to 120 hours per calendar year Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington up to 56 hours per calendar year Holiday pay, including Floating Holidays up to 13 days per calendar year of Work, Personal and Family Time - up to 40 hours per calendar year Additional information can be found through the link below. The compensation and benefits information set forth in this posting applies to candidates hired in the United States. Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market.
Job ID: 481322606
Originally Posted on: 6/15/2025
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