Senior Scientist, Preclinical Sciences & Translational Safety Translational Pharmacokinetics/Pharmacodynamics

• Job title Senior Scientist, Preclinical Sciences & Translational Safety Translational Pharmacokinetics/Pharmacodynamics
• Function Discovery & Pre-Clinical/Clinical Development
• Sub function Pharmacokinetics & Pharmacometrics
• Category Senior Scientist, Pharmacokinetics & Pharmacometrics (ST6)
• Location Spring House / San Diego / United States of America
• Date posted Jun 12 2025
• Requisition number R-016750
• Work pattern Hybrid Work

This job posting is anticipated to close on Jun 20 2025. We may however extend this time period, in which case the posting will remain available on www.careers.jnj.com to accept additional applications.

Description

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Pharmacokinetics & Pharmacometrics

Job Category:

Scientific/Technology

All Job Posting Locations:

San Diego, California, United States of America, Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at

We are searching for the best talent for a Senior Scientist, Preclinical Sciences & Translational Safety Translational Pharmacokinetics/Pharmacodynamics to be located in Spring House, PA or San Diego, CA.

Purpose: We are looking for a Translational PK/PD scientist to join our Translational Pharmacokinetics, Pharmacodynamics and Investigational Toxicology (TPPIT) group, part of Preclinical Sciences and Translational Safety (PSTS) organization. This position will be responsible for serving as a translational PK/PD representative on project teams, conducting mechanistic PK/PD studies and providing modeling and simulation support across multiple modalities (protein, ADC, synthetics, siRNA and cellular therapeutics), across multiple therapeutic areas. Using both experimental and computational tools, this individual will enable relevant forward and reverse translation for projects and platform efforts and support timely decision-making for programs across different stages of development.

You will be responsible for:

• Independently developing fit-for-purpose mathematical models (e.g., PK/PD, mechanism-based, QSP) to inform target selection, drug design, modality selection, candidate optimization and selection, and inform clinical study design (e.g., human PK/PD prediction, FIH dose selection, and efficacious dose projections) through identifying and addressing critical knowledge gaps.

• Determining and designing critical path experiments and delivering high quality results to effectively inform program decisions.

• Collaborating closely with biologists, chemists, protein engineers, toxicologists, bioanalytical scientists, clinical pharmacologists and clinicians to advance portfolio programs.

• Representing function in cross-functional project teams and communicating effectively to ensure scientific rigor.

Qualifications / Requirements:

Education:

• A minimum of a Bachelor's degree in Pharmaceutical Sciences, Clinical Pharmacology, Biological Sciences, Bioengineering, Chemical Engineering or Applied Mathematics is required. An advanced degree (Master's, PhD) is preferred.

Experience and Skills:

• At least 2 years of relevant experience (e.g., post-doc, industry) is required.

• Experience with quantitative approach in describing biological systems using preclinical and/or clinical data and demonstrated ability to use quantitative tools are required.

• Excellent communication skills and the ability to work independently and as a team member is required.

• Hands-on experiences in at least one of the modeling and simulation software (e.g., Monolix, NONMEM, Matlab, ADAPT5) is required.

• A strong publication record is preferred.

The anticipated base pay range for this position is $105,000 to $169,050.

The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation's performance over a calendar/performance year. Bonuses are awarded at the Company's discretion on an individual basis.

• Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.

• Employees may be eligible to participate in the Company's consolidated retirement plan (pension) and savings plan (401(k)).

• Employees are eligible for the following time off benefits:

• Vacation - up to 120 hours per calendar year

• Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington - up to 56 hours per calendar year

• Holiday pay, including Floating Holidays - up to 13 days per calendar year of Work, Personal and Family Time - up to 40 hours per calendar year

• Additional information can be found through the link below.

The compensation and benefits information set forth in this posting applies to candidates hired in the United States. Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market.

This job posting is anticipated to close on 06/19/2025. The Company may however extend this time-period, in which case the posting will remain available on to accept additional applications.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (...) or contact AskGS to be directed to your accommodation resource.

An internal pre-identified candidate for consideration has been identified. However, all applications will be considered.

#LI-Hybrid

The anticipated base pay range for this position is :

The anticipated base pay range for this position is $105,000 to $169,050.

Additional Description for Pay Transparency: