PAT Scientist III

Work Schedule

Standard (Mon-Fri)

Environmental Conditions

Adherence to all Good Manufacturing Practices (GMP) Safety Standards, Laboratory Setting, Loud Noises (Equipment/Machinery), Office, Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.)

Job Description

As a Manufacturing Scientist, you will contribute to the development, validation, and optimization of chemometric models for oral solid dosage (OSD) products, specifically in our Continuous Manufacturing line. The ideal candidate brings expertise in Chemometrics , multivariate data analysis , and programming skills (Python, R, and/or MATLAB) to support model-based control, real-time monitoring, and data-driven decisions. You will collaborate with multi-functional teams and clients to improve process performance and ensure model lifecycle adaptability. Experience in process modeling and/or OSI PI is a plus. What will you do?

• Support the development, deployment, and lifecycle management of Process Analytical Technology (PAT) tools and multivariate models used in continuous manufacturing.

• Apply chemometric techniques (e.g., PCA, PLS) to develop, validate, and maintain predictive and/or classification models for process monitoring and control.

• Analyze process and spectral data to support investigations, trend analysis, and performance supervising across product lifecycle stages.

• Collaborate with operations, quality, engineering, and analytical teams to ensure robust process control and monitoring.

• Serve as the technical lead on client-facing projects and provide scientific justifications for model performance, control strategies, and data use.

• Author protocols, reports, and documentation aligned with GMP and regulatory requirements.

• Support the integration of process data infrastructure, visualization, and analytics tools (e.g., dashboards) into manufacturing workflows.

• Provide day-to-day technical support for commercial CM processes and act as scientific owner for assigned products.

Education

Bachelors degree in Chemical Engineering, Pharmaceutical Sciences, Chemistry, Data Science, or a related field is required. A Masters or Ph.D. with a focus on Chemometrics , process systems engineering , or data analytics is preferred.

Experience

• Minimum of 5 years proven experience with a Bachelors degree

• Minimum of 2 years with a Masters degree

• No prior experience required with a Ph.D. if coursework and research align with Chemometrics, continuous manufacturing , or process modeling

• Hands-on experience with continuous manufacturing , PAT model development , and spectroscopy techniques (e.g., NIR, Raman)

Knowledge, Skills, Abilities

• Proficiency in programming language for data analysis, modeling, and visualization

• Proven understanding of multivariate statistical analysis , data preprocessing, and validation methods

• Familiarity with GMP , FDA/EMA guidelines, and ICH standards related to PAT and model validation

• Experience with process control , model monitoring , or data integrity frameworks preferred

• Excellent communication and problem-solving skills with the ability to lead multi-functional discussions

• Organized, dedicated, and able to prioritize in a fast-paced environment

Physical Requirements

Position requires standard mobility and coordination to navigate office and manufacturing spaces; ability to stand, walk, kneel, and occasionally lift items between 1035 pounds. Prolonged keyboard and screen use may be required.

Join Us
At Thermo Fisher Scientific, your technical skills will directly support ground breaking continuous manufacturing initiatives. Help us drive innovation and deliver high-quality medicines faster and more efficiently.

Apply today:

Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate