Scientist

Job Description

• The Biotherapeutics and Genetic Medicine Group is seeking a highly motivated scientist for initiating the lentiviral delivery platform for gene therapy in a newly established Genetic Medicine team.

• The candidate will work collaboratively with cross-functional and therapeutic area teams to advance company's lentiviral gene therapy pipeline.

• Collaborate with cross-functional and therapeutic area teams to advance novel lentiviral vectors into pipeline

• Design and engineer lentiviral vectors and manage lentiviral production by leveraging internal and CRO resources.

• Help build and establish analytical and cell-based screening assays (e.g., p24, VCN, SupT1 titration, ELISA, qPCR, ddPCR, WES, FACS, and endotoxin assay)

• Maintain a comprehensive Electronic Lab Notebook documenting experiments

• Maintain a high level of productivity in the team with clear daily, detailed, and accurate documentation of experiments

• Author technical reports and protocols

• Understand and enforce company culture, teamwork, safety, appropriate handling of materials in an BSL2 environment

• Perform all activities in compliance with applicable regulations, policies and guidelines

• Bring a spirit to work and deliver on other responsibilities as assigned

Qualifications

• Ph.D. in biology or a relevant field with 5+ years of experience in lentiviral vector-based gene therapy in addition to post-doctoral experience; or MS with at least 10 years of relevant experience; industrial experience highly desired

• Strong expertise and experience in lentiviral vector design, engineering and production

• Experience in managing CROs for lentiviral production

• Experience in analytical and screening methods for characterization of lentiviral vector products

• Experience in CAR-T cell therapy

• Experience in in vivo lentiviral targeted delivery is a plus

• Ability to work effectively in a highly collaborative and dynamic environment

• Excellent verbal and written communication skills

• Excellent organization and collaborative skills

• Detail oriented with a passion to deliver quality

• The ideal candidate will have strong expertise and experience in lentivirus vector engineering, production, analytics and in vitro screening, as well as experience in managing CROs for lentiviral production.

Benefits:

Healthcare Insurance: Synectics offers eligible employees and their dependents healthcare coverage through BlueCross BlueShield of Illinois. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics. Premiums are subsidized by Synectics.

Dental Insurance: Synectics offers eligible employees and their dependents a dental plan through MetLife. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.

Vision Insurance : Synectics offers eligible employees vision insurance through VSP. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.401(k) Plan: The Synectics Inc. Investment Savings Retirement Plan. Synectics offers all employees who are 21 years of age or older the opportunity to invest in the 401(k) Plan on the first enrollment date that is at least 30 days after employment begins. Enrollment dates are each January 1st, April 1st, July 1st, and October 1st.

Technical Certification Bonus: Synectics is pleased to award its employees a bonus of up to $500 for an approved professional certification. In determining the bonus amount, Synectics will consider the cost of the test(s) for any certification relating to your current position, achieved during your employment with us. Only one Certification Bonus per calendar year may be awarded per employee. Only current, active employees will be eligible to receive this bonus. It will be awarded 90 days after the Synectics office has received documentation confirming the successful completion of the certification.

Synectics is an equal opportunity employer.