Associate Scientist

Associate Scientist

Lexington, MA

Date Posted:23-Jun-2025

Work Type:On-Site

Job Number:458294

Job Description

Job Title: Associate Scientist

Duration: 12+ Months (Potential)

Location: Lexington, MA, 02421

Job Description:

The Position

Client is seeking a highly motivated Associate Scientist II to join the Oligonucleotide Chemistry Team in Lexington, Massachusetts. The candidate will be responsible for analysis and purification of oligonucleotides. This position will support therapeutic programs in multiple disease areas and will contribute to the development of novel nucleic acid conjugate platforms. Prior experience in LCMS method development and oligonucleotide purification and characterization is desired.

Relationships

This position reports to the Director, Oligonucleotide Chemistry as an individual contributor. Daily interaction with other peers in oligo synthesis, medicinal chemistry and biology teams in support of early phase product pipeline.

Essential Functions

Primary responsibility to provide analytical lab support for Client's Oligonucleotide early phase pipeline

Development of robust LC/MS, IPRP and SAX analytical methods for analysis and purification of highly modified oligonucleotide drug substances.

Prepare analytical samples, analyze and process data, primarily by UPLC, LC-MS

Operate, maintain and troubleshoot lab instruments

Conduct and help design unique experiments to help in characterization of highly modified oligonucleotides and sgRNA

Keep accurate records of the experiments and summarize the results in well communicated presentations or written reports

Purification, deprotection, annealing and lyophilization of oligonucleotides to support all disease programs

Oligonucleotide synthesis

Possess excellent written and verbal communication skills

Conduct laboratory work in an efficient manner that ensures a safe working environment

Qualifications:

MS or BS with 3+ years of industrial experience

Strong knowledge of mass spectrometry and purification techniques

Experience with waters LC/MS instruments preferred

Experience with purification and LC/MS analysis of sgRNA highly preferred

Experience with analytical techniques e.g. RP-UPLC, SAX-HPLC, LC-MS and data interpretation

Strong background in the analytical development of methods for the analysis of oligonucleotide therapeutics

Experience with IP-RP-UHPLC and AX-HPLC analytical techniques using Ag-ilent, Waters and/or Thermo UHPLC's and associated software

In depth knowledge of GLP/GMP's in a pharmaceutical environment

The successful candidate must possess excellent writing and communication skills and a demonstrated ability to work independently and with cross-functional teams

Applicant Notices & Disclaimers

For information on benefits, equal opportunity employment, and location-specific applicant notices, click here

At SPECTRAFORCE, we are committed to maintaining a workplace that ensures fair compensation and wage transparency in adherence with all applicable state and local laws. This position's starting pay is: $40.00/hr.