Principal Scientist, Preclinical Safety & Translational Sciences-Translational Pharmacokinetics/Phar
- Johnson and Johnson
- Spring House, Pennsylvania
- Full Time
Location: Spring House, US-PA
Rate: Not Specified
Type: Permanent
Principal Scientist, Preclinical Safety & Translational Sciences-Translational Pharmacokinetics/Phar
At Johnson & Johnson,we believe health is everything.
Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at
Job Function:
Discovery & Pre-Clinical/Clinical Development
Job Sub Function:
Pharmacokinetics & Pharmacometrics
Job Category:
Scientific/Technology
All Job Posting Locations:
San Diego, California, United States of America, Spring House, Pennsylvania, United States of America
Job Description:
About Innovative Medicine
Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements.
Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
Learn more at
Purpose: The Principal Scientist will be a key member of discovery project teams and interact closely with biology, chemistry, and other drug metabolism and pharmacokinetic (DMPK) project members to help craft the most appropriate preclinical and early clinical studies and the associated quantitative model-based analyses to advise candidate selection and dosing recommendations.
Modeling approaches used may include physiologically-based pharmacokinetic modeling, mechanistic PK/PD modeling, and/or systems pharmacology modeling to help (a) predict preclinical and clinical PK profiles (b) quantify exposure/ response relationships for target engagement biomarkers, efficacy, and potential adverse effects, and (c) guide in vivo and in vitro experimental designs that will be most informative for modeling.
We are searching for the best talent for a Principal Scientist, Preclinical Safety & Translational Sciences-Translational Pharmacokinetics/Pharmacodynamics to be located in Spring House, PA or La Jolla, CA.
You will be responsible for:
* Applying Pharmacokinetic/Pharmacodynamic (PK/PD) modeling to drive project team decisions from early discovery through early clinical studies.
* Contributing to guide modeling and simulation strategies within the organization.
Qualifications / Requirements:
Education:
* PhD in Pharmacology, Engineering, Mathematics, Physics, or a related field with 4+ years of relevant industry experience OR a Master's degree with 6+ years of relevant industry experience is required.
Experience and Skills:
* Strong familiarity with principles of pharmacokinetics and pharmacodynamics and experience performing PK and/or PK/PD modeling is...
Rate: Not Specified
Location: Spring House, US-PA
Type: Permanent
Industry: Other
Recruiter: Johnson and Johnson
Contact: Not Specified
Email: to view click here
Reference: R-018751
Posted: 2025-06-25 08:16:37 -
Rate: Not Specified
Type: Permanent
Principal Scientist, Preclinical Safety & Translational Sciences-Translational Pharmacokinetics/Phar
At Johnson & Johnson,we believe health is everything.
Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at
Job Function:
Discovery & Pre-Clinical/Clinical Development
Job Sub Function:
Pharmacokinetics & Pharmacometrics
Job Category:
Scientific/Technology
All Job Posting Locations:
San Diego, California, United States of America, Spring House, Pennsylvania, United States of America
Job Description:
About Innovative Medicine
Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements.
Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
Learn more at
Purpose: The Principal Scientist will be a key member of discovery project teams and interact closely with biology, chemistry, and other drug metabolism and pharmacokinetic (DMPK) project members to help craft the most appropriate preclinical and early clinical studies and the associated quantitative model-based analyses to advise candidate selection and dosing recommendations.
Modeling approaches used may include physiologically-based pharmacokinetic modeling, mechanistic PK/PD modeling, and/or systems pharmacology modeling to help (a) predict preclinical and clinical PK profiles (b) quantify exposure/ response relationships for target engagement biomarkers, efficacy, and potential adverse effects, and (c) guide in vivo and in vitro experimental designs that will be most informative for modeling.
We are searching for the best talent for a Principal Scientist, Preclinical Safety & Translational Sciences-Translational Pharmacokinetics/Pharmacodynamics to be located in Spring House, PA or La Jolla, CA.
You will be responsible for:
* Applying Pharmacokinetic/Pharmacodynamic (PK/PD) modeling to drive project team decisions from early discovery through early clinical studies.
* Contributing to guide modeling and simulation strategies within the organization.
Qualifications / Requirements:
Education:
* PhD in Pharmacology, Engineering, Mathematics, Physics, or a related field with 4+ years of relevant industry experience OR a Master's degree with 6+ years of relevant industry experience is required.
Experience and Skills:
* Strong familiarity with principles of pharmacokinetics and pharmacodynamics and experience performing PK and/or PK/PD modeling is...
Rate: Not Specified
Location: Spring House, US-PA
Type: Permanent
Industry: Other
Recruiter: Johnson and Johnson
Contact: Not Specified
Email: to view click here
Reference: R-018751
Posted: 2025-06-25 08:16:37 -
Job ID: 483221789
Originally Posted on: 6/28/2025
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