Associate Scientist II, Biology

Responsibilities will include designing, developing, and executing studies in rodent disease models, evaluation of small interfering RNAs (siRNAs) in wild-type animals, and conducting the associated in vitro molecular-based assays such as transcript and protein quantitation. Contribute to study design and execution of studies to characterize molecules for RNAi therapeutic programs, including rodent disease models Develop and conduct assays such as qPCR, western blot, ELISA, and flow cytometry/FACS, that support in vivo studies Perform in vitro and cell-based assays to characterize drug activity Perform in vivo procedures in rodents, including administration of therapeutics via established methodologies Analyze and interpret the data Prepare clearly articulated experimental reports and data presentations Prepare of SOPs/protocols Present data to groups within and outside of Research Minimum B.S. degree in a life sciences-related discipline such as Molecular Biology, Cell Biology, or Genetics 1+ years of experience in laboratory research Proficiency in RNA/DNA/protein analysis techniques, including ELISA, western blotting and qPCR Cell/tissue culture experience Flow cytometry or FACS experience is a plus Basic rodent in vivo skills (animal handling, subcutaneous/intravenous dosing, blood collection, and necropsy/dissection expertise) Experience setting up rodent disease models is a plus Ability to perform and troubleshoot assays independently or with limited direction of supervisor(s)/project leader(s) Demonstrate keen knowledge of experimental design, underlying scientific principles, and the ability to rigorously and independently analyze results, propose future directions and generate clear reports Must be flexible, open to new tasks and challenges and able to work on tight deadlines Proven ability to work in a team environment and across functional areas Cover letter encouraged