Principal Scientist, In Silico Discovery - Biologics

• Job title Principal Scientist, In Silico Discovery - Biologics
• Function Discovery & Pre-Clinical/Clinical Development
• Sub function Biological Research
• Category Principal Scientist, Biological Research (ST7)
• Location Spring House / San Diego / Cambridge / United States of America
• Date posted Jul 01 2025
• Requisition number R-017600
• Work pattern Hybrid Work

Description

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Biological Research

Job Category:

Scientific/Technology

All Job Posting Locations:

Cambridge, Massachusetts, United States of America, San Diego, California, United States of America, Spring House, Pennsylvania, United States of America

Job Description:

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at

We are seeking a creative, self-motivated Principal Scientist to join our In Silico Discovery Biologics team located in either Spring House, PA, Cambridge, MA or San Diego, CA. As we expand our AI/ML capabilities in antibody design and multifunctional molecule optimization, we are looking for an experienced scientist to play a key role in applying methods from this initiative to advance therapeutic molecules. The ideal candidate will be a highly collaborative researcher eager to impact biologics design and development using computational techniques. This is an exciting opportunity to join an enthusiastic, diverse, and global community of in silico scientists committed to bringing innovative new medicines to patients.

The Principal Scientist will collaborate with Biologics Discovery (BD) scientists to effectively apply AI/ML models, thereby enhancing the antibody discovery process. This role involves leveraging advanced computational techniques and data analysis to accelerate the identification and optimization of antibody candidates. By integrating AI/ML models with experimental data, the team will aim to predict candidate efficacy, facilitate design decisions, and streamline the overall workflow from initial screening to lead optimization. Additionally, fostering cross-disciplinary collaboration and continuous knowledge sharing between in silico approaches and laboratory efforts will be crucial for driving successful outcomes in antibody development.

Primary Responsibilities

• Partner closely with Biologics Discovery teams to drive drug discovery projects through application of predictive and AI/ML tools for biologics design and optimization.
• Mentor junior scientists, fostering their development as expert informatics scientists.
• Engage in industry consortia and represent J&J and In Silico Discovery in key initiatives.
• Periodically be tasked with evaluating and making recommendations for the acquisition or building of new technologies. This may include performing Due Diligence on potential partnering/M&A opportunities.
• Contribute to an inspiring, scientifically rigorous, and innovative culture that embraces continuous learning, development, and collaboration.
• Contribute towards efforts to influence J & J's external environment via external scientific publications in peer-reviewed journals and via participation in external conferences as needed.

Qualifications

Required:

• A PhD and a minimum of 4 years of experience in drug development with industry or related leadership experience.
• Demonstrated expertise in the field of AI/ML, computation, and antibody design & optimization in drug discovery
• Strong understanding of pharmaceutical discovery and optimization processes.
• Hands-on experience with large scale data curation, aggregation, manipulation, integration, mining, and analysis, including structured and unstructured data sources.

Preferred:

• Experience in generating data visualizations in tools (e.g. Spotfire, Vortex, Tableau).
• Ability to organize and communicate complex data sets in a clear and concise manner to key business partners from diverse backgrounds
• Prior experience working with or leading collaborations with external academic, biotechnology, and contract research organizations.
• Strong publications and/or proven record of supporting discovery of clinical/pre-clinical candidates.
• Strong motivation, passion, and commitment to science and patients.
• This is a hybrid role that can be located in either Spring House, PA, Cambridge, MA or San Diego, CA, (no fully remote option available). Travel up to approximately 5% yearly may be required (domestic and international).

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, please contact us via or contact AskGS to be directed to your accommodation resource.

The anticipated base pay range for this position is $115,000 to $197,800. The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation's performance over a calendar/performance year. Bonuses are awarded at the Company's discretion on an individual basis. Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance. Employees may be eligible to participate in the Company's consolidated retirement plan (pension) and savings plan (401(k)).

Employees are eligible for the following time off benefits:

Vacation - up to 120 hours per calendar year

Sick time - up to 40 hours per calendar year

Holiday pay, including Floating Holidays - up to 13 days per calendar year of Work, Personal and Family Time - up to 40 hours per calendar year

Additional information can be found through the link below.

The compensation and benefits information set forth in this posting applies to candidates hired in the United States. Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market.

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