Sr. Scientist, Downstream Purification

Job Description

Are you ready to make a significant impact in the world of biopharmaceuticals? At our Company, we are at the forefront of innovation in the Manufacturing Division, specifically within the Biologics Drug Substance Commercialization (BDSC) team. Our Downstream Purification department is dedicated to leading the charge in downstream processing for late-stage pipeline and commercial drug substance manufacturing, focusing on life-saving therapeutics.

As a Senior Scientist, you will play a pivotal role in shaping the future of biopharmaceutical manufacturing. Working under the guidance of our technical leader in downstream processing, you will collaborate with both internal and external partners to support our late-stage programs. Your scientific expertise and experimental skills will be crucial in driving our mission forward.

Key Responsibilities:

• Innovate and Collaborate: Join dynamic teams focused on late-stage commercial process development, process characterization, and technology transfer, all aimed at achieving product licensure and commercialization.

• Lead Laboratory Studies: Conduct laboratory-scale studies that support commercial process validation and characterization, whether in-house or through external partnerships.

• Drive Technical Excellence: Provide technical leadership in designing experiments, analyzing data, and executing or managing laboratory activities.

• Expand Your Expertise: While your primary focus will be on downstream processing, you will gain insights into various aspects of drug substance manufacturing, including cell culture and analytical methods.

• Engage with Partners: Actively interact with internal and external stakeholders, representing your functional area on cross-functional teams.

• Document Your Impact: Author essential regulatory and technical documentation, ensuring that all processes and products meet our high standards.

Minimum Education Requirement and Experience:

• BS in Biological Sciences, Chemical Engineering, Biological Engineering, or Chemistry, with six (6) years of relevant experience required. OR

• MS in Biological Sciences, Chemical Engineering, Biological Engineering, or Chemistry, with four (4) years of relevant experience required. OR

• PhD in Biological Sciences, Chemical Engineering, Biological Engineering, or Chemistry, with no experience.

Required Skills:

• A solid technical background in the purification of biological molecules, including hands-on experience with chromatography and filtration systems.

• Strong foundational knowledge in downstream processing of biologics.

• Exceptional communication skills, with the ability to articulate complex process science concepts to drive decision-making in a multidisciplinary team environment.

Preferred Skills:

• In-depth experience with downstream purification techniques, particularly preparative chromatography, tangential flow filtration, and virus-retaining filtration.

• Familiarity with technology transfer and scaling processes for biologics manufacturing.

• Experience in late-stage process development, including viral clearance studies and regulatory submissions.

• Proficiency in statistical methods for design of experiments (DOE) and data analysis, using tools like JMP.

• Understanding of analytical methods for characterizing biologics and knowledge of US/EU regulatory requirements and cGMPs is a plus.

At our Company, you will be part of a passionate team that is dedicated to advancing biopharmaceutical manufacturing. You will have the opportunity to work on groundbreaking projects that directly impact patient care and contribute to the development of life-saving therapies. If you are ready to take your career to the next level and make a difference in the world, we want to hear from you!

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one anothers thinking and approach problems collectively.

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U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as remote.

The salary range for this role is

$114,700.00 - $180,500.00

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employees position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at .

You can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

VISA Sponsorship:

Travel Requirements:

Flexible Work Arrangements:

Hybrid

Shift:

Valid Driving License:

Hazardous Material(s):

Required Skills:

Adaptability, Bioreactors, cGMP Regulations, Chemical Engineering, Chromatographic Techniques, Clinical Judgment, Communication, Design of Experiments (DOE), Detail-Oriented, Good Manufacturing Practices (GMP), Process Design, Process Optimization, Process Scale Up, Science, Small Molecule Synthesis, Social Collaboration, Strategic Planning, Technology Transfer

Preferred Skills:

Job Posting End Date:

07/18/2025

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.