Senior Scientist, Technical Development, Analytical

About Voyager Therapeutics

Voyager Therapeutics, Inc. (Nasdaq: VYGR) is a biotechnology company dedicated to leveraging the power of human genetics to modify the course of - and ultimately cure - neurological diseases. Our pipeline includes programs for Alzheimer's disease, Friedreich's ataxia, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and multiple other diseases of the central nervous system. Many of our programs are derived from our TRACER AAV capsid discovery platform, which we have used to generate novel capsids and identify associated receptors to potentially enable high brain penetration with genetic medicines following intravenous dosing. Some of our programs are wholly owned, and some are advancing with partners including Alexion, AstraZeneca Rare Disease; Novartis Pharma AG; and Neurocrine Biosciences, Inc. For more information, visit .

Voyager Therapeutics is a registered trademark, and TRACER is a trademark, of Voyager Therapeutics, Inc.

Job Summary:

Voyager Therapeutics is seeking an experienced Senior Scientist*, Physicochemical Methods, to join Analytical and Drug Product Development Team in Technical Development. This role will be a key subject matter expert in analytical chromatography and other methods for in depth characterization of various modalities including AAV-based vectors, bispecific antibodies and antibody-oligonucleotide conjugates. Prior experience with mass spectrometry is highly desirable.

Position Specific Responsibilities:

• Lead design, development, and qualification of analytical chemical/physicochemical methods for gene and protein therapies
• Devise strategies needed to progress products in the pipeline including process support, formulation and stability support, product release and characterization
• Oversee transfer, execution, and troubleshooting of physicochemical methods at contract research organizations (CROs)
• Ensure quality of key results of major project plans through sound design, early risk assessments and mitigation. Track critical data and assay performance.
• Train junior team members and review data
• Author and review SOPs, analytical protocols, technical reports, and regulatory submission documents
• Closely collaborate with Process Development and Pilot Manufacturing
• Establish working relationships with Research to provide characterization of development candidates and ensure seamless transition from Research to Development

Requirements:

• PhD in analytical chemistry, biochemistry or related field with 5+ years of industry experience; Masters with 10+yrs experience; BS with 12+ yrs experience
• A deep knowledge of various analytical techniques: chromatography methods (SEC, IEX, affinity), Capillary Electrophoresis, DLS, spectroscopy
• Prior experience managing contract research organizations (CROs) is desired
• Familiarity with mass spectrometry and AUC is desired
• Ability to handle multiple projects, meet deadlines and make decisions
• Excellent organizational and communication skills
• Understanding of regulatory and compendial expectations for analytical methods, assay qualification and validation; experience supporting regulatory filings is preferred
• Demonstrated ability to multi-task and be highly productive in a fluid and fast-paced environment
• Position level determined by candidate experience, qualifications, and competencies