Principal Scientist- Contract

The successful candidate will join a team dedicated to developing functional assays on primary immune cells and tumor cells to assess combinatory therapeutics in vaccine and oncology assets. This includes checkpoint inhibitors, bispecific antibodies, and costimulatory bispecific antibodies. The role requires evaluating the immunogenicity of targets to support cancer vaccine development and contributing to a platform that assesses potential immunogenicity risks of therapeutic proteins.

Responsibilities

• Independently develop and execute primary human immune cell functional assays.
• Perform co-culture assays of immune cells and tumor cells.
• Conduct in vitro cell engineering, characterization, and functional assays, such as TCR engineering.
• Analyze data using flow cytometry to characterize human immune cells.
• Perform data analysis, troubleshoot experiments, and record results in an electronic notebook.
• Collaborate with multiple teams to achieve shared project goals.

• Proficiency in T Cell Assays or Co-Culture assays.
• Experience with flow cytometry.
• PhD with 5+ years postdoctoral or industrial experience, an MS with 8+ years, or a BS with 10+ years of experience in immunology, vaccine research, cancer biology, or related field.
• 5+ years of experience in developing primary human cell-based in vitro/ex vivo functional assays.

• Experience in flow cytometry analysis is a plus.

The role is based in a laboratory and vivarium environment, requiring onsite presence five days per week. The team is part of the Vaccine Immune Cell team in Vaccine Technology, offering a collaborative and dynamic work atmosphere. The company provides exceptional growth opportunities, with plans for significant expansion over the next five years, including the addition of 4,000 employees to the Tarrytown campus. Employees benefit from excellent company culture, a fully equipped gym and cafeteria onsite, and comprehensive employee packages including stock options, equity, bonuses, RSUs, and 401k matching. Contract employees receive accrued sick and vacation time along with paid holidays.

Pay and Benefits

The pay range for this position is $60.00 - $65.00/hr.

Eligibility requirements apply to some benefits and may depend on your job
classification and length of employment. Benefits are subject to change and may be
subject to specific elections, plan, or program terms. If eligible, the benefits
available for this temporary role may include the following:

Medical, dental & vision
Critical Illness, Accident, and Hospital
401(k) Retirement Plan Pre-tax and Roth post-tax contributions available
Life Insurance (Voluntary Life & AD&D for the employee and dependents)
Short and long-term disability
Health Spending Account (HSA)
Transportation benefits
Employee Assistance Program
Time Off/Leave (PTO, Vacation or Sick Leave)

Workplace Type

This is a fully onsite position in Tarrytown,NY.

Application Deadline

This position is anticipated to close on Jul 19, 2025.

About Actalent

Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.

The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing due to a disability, please email ... for other accommodation options.