TEMP - Scientist, Lead Generation Biology

Who We Are:

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs.

What We Do:

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit neurocrine.com , and follow the company on LinkedIn , X and Facebook . ( *in collaboration with AbbVie )

About the Role: Integral member of the In Vitro Neurobiology-Pharmacology team, supporting multiple early/late-stage drug discovery projects across novel targets. Brings expertise in a broad range of assay technologies using both iPSC-derived and rodent primary cellular platforms. Proficient with diverse automated systems and instrumentation. Actively contributes to enhancing research quality and driving process efficiency within a collaborative and fast-paced environment.

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Your Contributions (include, but are not limited to):

• Assay Development: Designs and develops novel biophysical and cell-based assays using mammalian cell lines (e.g., HEK-293, SH-SY5Y), human iPSC-derived neurons, astrocytes, and microglia, rodent primary cells, and human/rodent whole blood

• Assay Execution: Conducts routine assays to support lead identification and optimization across various therapeutic modalities including small molecules, antibodies, and peptides

• Mechanism of Action (MOA) Studies: Leads experimental work to investigate compound MOA

• Data Analysis & Reporting: Analyzes, interprets, and communicates experimental results; ensures timely and accurate documentation

• Assay Monitoring: Tracks assay performance, implements troubleshooting, and ensures data reliability

• Core Technical Skills:

  Aseptic cell culture

  Mammalian cell transfections

  Molecular biology (qPCR, Western Blot)

  Flow cytometry (FACS)

  ELISA, cytokine release, and reporter cell assays

  Calcium flux, AlphaLISA, NanoBRET, and phagocytosis assays

  High-content imaging

• Continuous Improvement: Actively contributes to enhancing lab workflows, increasing process efficiency, and ensuring high research quality

• Additional Responsibilities: Supports other team functions and projects as needed in a dynamic and collaborative environment

Requirements:

• BS/BA degree in scientific field and 2+ years of neurobiology/in vitro pharmacology experience; Preferred experience includes: iPSC-derived cellular systems, rodent primary cell culture, and related assay development, liquid handling automation and LIMS systems

• MS/MA degree in scientific field and some relevant industry experience

• PhD in biology or related field preferred and experience with neurobiology, cell-based in vitro assays, development and optimization of in vitro biological assays is required. Preferred experience includes: iPSC-derived cellular systems, rodent primary cell culture, and related assay development, liquid handling automation and LIMS systems

• Collaborative and highly motivated

• Must be comfortable working with radioisotopes

• Working knowledge of primary cell culture, especially CNS (human iPSC-derived neurons/astrocytes/microglia cellular systems, rodent primary cells (neurons, astrocytes microglia), human and rodent whole blood) and related in vitro assay development, liquid handling automation and LIMS systems

• Recognizes fundamental anomalies in data points and identifies issues in experiments / processes

• Begins to understand how to think outside of the technical process and consider the impact decisions will have on the broader scientific goals

• Strong knowledge of one scientific discipline

• Good knowledge of scientific principles, methods and techniques

• Good knowledge and demonstrated ability working with a variety of laboratory equipment/tools

• Ability to work as part of a team

• Strong computer skills

• Good communications, problem-solving, analytical thinking skills

• Detail oriented

• Ability to meet deadlines

• Good project management skills

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Neurocrine Biosciences is an EEO/Disability/Vets employer.

We are committed to building a workplace of belonging, respect, and empowerment , and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications dont line up to exactly what we have outlined in the job description.