Bioinformatics Scientist II Associate

  • Spectraforce Technologies
  • Cambridge, Massachusetts
  • Full Time
Bioinformatics Scientist II Associate

Spectraforce Technologies

United States, Massachusetts, Cambridge

Jul 18, 2025

Position Title: Bioinformatics Scientist - II (Associate)

Work Location: Cambridge, MA 02141

Assignment Duration: 23 months

Work Schedule: M-F 8-5

Work Arrangement: Onsite

Position Summary: The Precision Genetics group seeks a data scientist for multi-modal, multi-scale data analyses to support innovative research efforts.

Background & Context:

Department: Data and Genome Sciences

Group: Precision Genetics

The Precision Genetics group within the Data and Genome Sciences Department is seeking a skilled Contractor to join our Computational Precision Immunology team.

Key Responsibilities:

Data Ingestion: Query external databases to acquire relevant multi-omics datasets (e.g., PubMed, Gene Expression Omnibus, ArrayExpress, gnomAD, GTEx, Ensembl).

RNA-seq Analysis: Perform quality control (QC) and analysis of bulk and single-cell RNA-seq data using state-of-the-art methods (e.g., FastQC, STAR, Limma, DESeq2, clusterProfiler, Seurat, scanpy, LeafCutter).

Multi-Omics Analysis: Analyze diverse molecular data types including spatial transcriptomics (e.g., Slide-seq, MERFISH, squidpy) and proteomics (e.g., OLINK, mass spectrometry-based approaches).

Data Integration: Integrate multi-omics datasets, including gene/protein expression, mRNA splicing, spatial transcriptomics, and genotype data.

Documentation: Prepare detailed documentation of analysis methods and results in a timely manner.

Qualification & Experience:

Ph.D. in Computational Biology or a related field.

A proven track record of over 3 years in multi-omics analysis.

Fundamental understanding of statistical methods and multi-omics data analysis and integration (e.g., RNA-Seq, single-cell RNA-Seq, genotype, spatial transcriptomics, OLINK).

Proficiency in R, Python, and Bash, with the ability to establish best practices for reproducible data analyses.

Experience with high-performance computing (HPC) systems and AWS Cloud Computing (e.g., IAM, S3 buckets).

A collaborative and self-motivated individual with a strong work ethic, capable of managing multiple objectives in a dynamic environment and adapting to changing priorities.

Excellent written and verbal communication skills.

Preferred: Experience in processing and analyzing real-world data.

Preferred: Familiarity with spatial transcriptomics analysis.

Preferred: Knowledge of statistical and population genetics principles.
Job ID: 486148097
Originally Posted on: 7/20/2025

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