Scientist

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. Were looking for people who are determined to make life better for people around the world.

Organization Overview:

At Lilly, we serve an extraordinary purpose. For more than 140 years, we have worked tirelessly to discover medicines that make life better. These discoveries start in Lilly Research Laboratories, where our scientists work to create new medicines that will help solve our worlds greatest health challenges.

Purpose of the Job:

Clinical Diagnostics Laboratory (CDL) develops and implements clinical, pre-clinical and translational biomarkers to support Discovery research, Clinical Trial sample analysis and Companion Diagnostic development. Scientists in the CDL develop, validate and implement prototype Diagnostic biomarker assays and analyze human and animal samples to support Lilly Clinical Trials and Discovery Research.

Key Responsibilities of Job:

• Process clinical samples (e.g., plasma, FFPE tissue, frozen tissue) for translational and clinical studies according to SOPs.
• Daily operation, maintenance and hand-on troubleshooting of liquid chromatography-mass spectrometry (LC-MS) including Thermo Orbitrap and Waters Tandem Quad systems.
• Contribute to assay development, improving workflows and developing SOPs. Participate in regulated assay validation, quality assurance and result reporting.
• Analyze data, summarize results, and present key results at functional reviews and project reviews.
• Participate in the evaluation or development of new technologies that relate to clinical biomarkers and relevant commercial diagnostic platforms.
• Technical writing skills CDL scientists are required to author methods, reports, standard operating procedures (SOPs) and other documentation.
• Communication and information management CDL scientists will maintain notebooks, prepare and present data and use computer software such as Signals Notebook, JMP, R, or proteomics data visualization tools to organize, analyze and summarize data.
• CDL scientists may communicate with internal and external partners and present data to support decisions in cross-functional teams.
• Application of regulatory requirements CDL scientists are responsible for understanding and appropriately applying regulatory expectations as they relate to analytical method development, validation and execution of diagnostic assays.
• All laboratory procedures must be conducted and documented according to appropriate regulations. CDL scientists are expected to exhibit behavior that supports and promotes GRP/GCP or other regulatory guidance and adheres to all appropriate Lilly procedures and CAP/CLIA guidelines when applicable.
• CDL scientists drive innovation and continuous technology development to meet the demands of new therapeutic design and modality.
• Collaborating with the Development Team and the Automation Team to execute assay improvement experiments, new assay configurations, and validations.

Minimum Requirements:

• Bachelors degree in biochemistry, bioanalytical chemistry, or related field.
• Minimum of 1 years (postbaccalaureate) Mass Spec experience
• Prior experience of immunopurification-mass spectrometry (IP-MS) for analytical characterization of proteins from complex biologic samples.
• Qualified candidates must be legally authorized to be employed in the United States. Lilly does not anticipate providing sponsorship for employment visa status (e.g., H-1B, or TN status) for this employment position

Additional Skills/Preferences:

• Experience in the use of Skyline and MassLynx to analyze targeted proteomics datasets of clinical biomarkers is preferred.
• Experience with Thermo Orbitrap and Waters Tandem Quad systems
• One or more year(s) working experience in a regulated laboratory environment is preferred.
• Experience in the use of mass spectrometry-based assays to support human subjects research or clinical diagnostics.
• Excellent general laboratory skills and experience with laboratory characterization of biomacromolecules.
• Project Management skills.
• Experience with various assay platforms and multiple computer software applications including LIMS systems.
• Experimental design; scientific approach to problem solving; method development, optimization and analytical validation.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Womens Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidates education, experience, skills, and geographic location. The anticipated wage for this position is

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lillys compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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