Principal Scientist, Cancer Immunology

Working with Us
Challenging. Meaningful. Life-changing. Those arent words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. Youll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .

The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients. Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies. With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of Cancer biology and Immuno-oncology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area

Position Summary:

This position provides a chance to develop next-generation Cancer Immunology therapies that improve patient outcomes. We seek an innovative scientist with leadership potential to drive drug discovery from target nomination to IND filing within the Discovery Biology Team at Bristol Myers Squibb in Cambridge, MA. The ideal candidate will be motivated, independent, and able to work within and lead cross-functional antibody discovery teams. supporting patient and indication selection as well as the development of a biomarker plan.

The candidate will guide matrixed teams through early target validation to IND filing and oversee a small group focused on in vitro biology, assay development, and compound screening studies. Proficiency in flow cytometry, mid-scale screening, T cell bioassays, molecular biology, and related methods is required.

This role also involves contributing to the nomination and advancement of new Cancer Immunology targets addressing immune suppressive and other cells in the tumor microenvironment. Collaboration with bioinformaticians and translational scientists is expected for experiment design and execution.

Position Responsibilities:

This role offers the opportunity to drive scientific innovation and shape the strategic direction of novel immunotherapy development at BMS in a highly collaborative environment that is guided by strong science and an enduring drive to benefit patients with cancer.

In the role as a Principal Scientist within Discovery Biology, the ideal candidate will:

• Apply comprehensive expertise in cancer immunology and antibody drug discovery to lead cross-functional discovery teams from target identification through IND submission.

• Oversee and actively contribute to the activities of the biology team, ensuring effective support for in vitro experimental workflows.

• Integrate internal screening data, reverse translational datasets, and insights from scientific literature to propose and develop innovative strategies in Cancer Immunology.

• Collaborate with leaders from key functional areas such as in vivo pharmacology, translational biology, DMPK, informatics, and predictive science to establish priorities, evaluate risks, and advance project objectives.

• Leverage advanced scientific and technical knowledge to design, validate, and conduct in vitro assays that clarify drug mechanisms of action and enhance therapeutic efficacy.

• Analyze complex biological data to support informed decision-making and guide optimization of lead candidates.

• Communicate scientific results and strategic recommendations clearly and effectively across the BMS organization.

• Demonstrate strong communication and interpersonal abilities to promote collaboration across multidisciplinary teams.

Experience = We are seeking a motivated scientist who combines deep immunology expertise with a passion for innovation. You thrive in a collaborative environment, enjoy solving complex biological problems, and are driven by the opportunity to make a meaningful impact on patients lives.

Basic Qualifications:

• Bachelors Degree

  • 8+ years of academic and / or industry experience

Or

• Masters Degree

  • 6+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences

  • 4+ years of academic and / or industry experience

Preferred Qualifications

• Ph.D. or equivalent advanced degree in the Life Sciences

  • 4+ years of academic and / or industry experience

• Proven expertise in the discovery and development of advanced biologics that influence immune function, including bispecific antibodies, biparatopic antibodies, masked antibodies, and immune cell engagers

• Extensive experience in designing, developing, and optimizing high-throughput cell-based assays for antibody screening

• Direct involvement in IND-enabling studies encompassing data generation, analysis, interpretation, and documentation

• Comprehensive understanding of cancer immunology with particular proficiency in T cell-based in vitro assays

• Demonstrated scientific curiosity, perseverance, and a strong commitment to resolving complex biological challenges through innovative approaches

• Strong leadership capabilities, with a history of mentoring or guiding scientific teams

• Superior organizational skills, adept at managing and prioritizing multiple projects involving both internal and external collaborators

• Established ability to analyse, interpret, and clearly communicate complex scientific data

• Exceptional verbal and written communication skills, effectively tailored to both scientific and cross-functional audiences

• Advanced problem-solving abilities with demonstrated application of scientific principles to address complex research questions

The starting compensation for this job is a range from $145,320.00 - $176,100.00, plus incentive cash and stock opportunities (based on eligibility).

The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit our BMS Career Site.

Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Years holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.

#LI-Onsite

If you come across a role that intrigues you but doesnt perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as Transforming patients lives through science , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ eeo -accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information:

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.