Senior Scientist, Discovery Chemistry

• Job title Senior Scientist, Discovery Chemistry
• Function Discovery & Pre-Clinical/Clinical Development
• Sub function Chemical Research
• Category Senior Scientist, Chemical Research (ST6)
• Location Spring House / United States of America
• Date posted Jul 24 2025
• Requisition number R-022462
• Work pattern Fully Onsite

This job posting is anticipated to close on Aug 01 2025. We may however extend this time period, in which case the posting will remain available on www.careers.jnj.com to accept additional applications.

Description

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Chemical Research

Job Category:

Scientific/Technology

All Job Posting Locations:

Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at

We are searching for the best talent for a Senior Scientist, Discovery Chemistry to be located in Spring House, PA.

Purpose: Building on a legacy of success, we are currently seeking an outstanding individual to join our team as Senior Scientist, Discovery Chemistry at our site in Spring House, PA. Our medicinal chemistry group is dedicated to the development of small molecule modalities, including peptide and protein degraders, as innovative therapeutics to combat diseases such as Alzheimer's disease, immunological disorders, and cancer.

We are seeking an enthusiastic experienced chemist with excellent organic synthesis expertise to advance drug discovery programs toward the clinic. In this laboratory-based position, the candidate will partner with both internal and external medicinal chemistry teams to generate innovative solutions to synthetic and medicinal chemistry challenges and collaborate across discovery functions including computer-assisted design scientists, biologists, pharmacologists, and pharmaceutical development scientists.

This individual must also excel in communication and have strong interpersonal skills necessary to influence in a collaborative multidisciplinary environment.

You will be responsible for:

• Maintaining a high level of productivity in the laboratory setting.

• Developing and implementing clear synthetic strategies towards complex molecules using innovative synthetic methodologies/technologies.

• Independently designing and synthesizing drug-like molecules using medicinal chemistry knowledge and an understanding of ADME, pharmacokinetics, optimal physicochemical properties, and AI/ML tools.

• Collaboratively supporting the advancement of compounds through in vitro and in vivo studies to identify development candidates.

• Collaboration with structure-based design groups to impact rational design of molecules.

• Contributing to defining scientific strategies and goals within a project team setting.

• Presenting data and reports on project status at individual, group, and departmental meetings.

• Publishing research in peer reviewed journals, and presenting work at scientific conferences.

Qualifications / Requirements:

Education:

• A PhD in synthetic organic or medicinal chemistry, or a Master's degree is required.

Experience & Skills:

• A minimum of 4 years of relevant experience (e.g., PhD, postdoc, industry) is required.

• Postdoctoral experience is preferred.

• Consistent track record of achievement in the synthesis of complex molecules and/or synthetic methodology development, with deep knowledge of modern synthetic & analytical techniques is required.

• Proven track record of scientific contributions including peer reviewed publications, patents and presentations is required.

• Experience with computational chemistry methods and biophysical techniques such as X-ray crystallography is preferred.

• Independent thinking and the ability to effectively collaborate in a highly diverse team environment is required.

• Excellent oral and written communication skills, including preparation of presentations is required.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (...) or contact AskGS to be directed to your accommodation resource.

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