FL114: Senior Research Associate, mRNA Sciences

About FL114:

FL114 is an innovative, privately held biotechnology company developing our novel epigenetic editing platform to treat a variety of diseases through precise, tunable modification of gene expression. FL114 was founded by Flagship Pioneering, where companies such as Moderna Therapeutics (NASDAQ: MRNA) and Seres Therapeutics (NASDAQ: MCRB) were conceived and created. With a strong emphasis on innovation and experimental execution, FL114 cultivates a highly dynamic and entrepreneurial environment.

About the Role:

FL114, Inc. is seeking a Senior Research Associate to join our integrated mRNA Sciences group as a key contributor in our efforts to develop mRNA therapeutics, as well as flexibly contributing to various workstreams across the company. The successful candidate will be an essential member of a close-knit team of experimental scientists driving FL114's product generation engine and supporting a broad set of therapeutic programs. We are looking for an enthusiastic, detail-oriented, adaptive, and highly motivated individual with a passion for bringing novel medicines to patients. Applicants should be comfortable working on a fast-paced, cross-functional scientific team, in an evolving role that will provide a variety of scientific experiences in mRNA therapeutics, epigenetics, and cellular biology.

Key Responsibilities:

• Produce and analyze high-quality mRNAs to support FL114 programs and partnerships
• Assist in the development of new and/or improved production and analytical workflows, including chromatography, gel electrophoresis, dot-blot, and bioluminescence
• Prepare and characterize mRNA-LNPs for in-vitro and in-vivo studies
• Perform routine and specialized cell culture procedures, including the maintenance and handling of primary human/mouse cells and established cell lines
• Conduct downstream analytical techniques on cell and tissue samples including qPCR, western blot and ELISA.
• Maintain accurate and detailed laboratory records of experimental design, protocols, raw data, and analyzed results.
• Assist in management of day-to-day laboratory operations including maintenance of equipment, as well as reagent tracking, ordering, and receiving
• Ensure adherence to laboratory safety practices and regulatory guidelines.

Required Skills:

• A flexible skill-set and an eagerness to learn and perform a variety of protocols spanning biochemistry, biophysics, molecular biology, and cellular biology
• Molecular biology techniques, including exposure to in-vitro transcription and biomolecular purification
• Tissue culture of mammalian cells, both suspension and adherent
• Preparation of lipid nanoparticles or other lipid-based formulations preferred
• Familiarity with cell-based assays such as flow cytometry, western blot, qPCR, ELISA, etc. preferred
• Exposure to high-throughput automation technologies, such liquid handing preferred
• Exposure to CRISPR-based or other gene editing technologies preferred
• Detail-oriented with excellent time management and organizations skills
• Exceptional teamwork and communication skills

Required Qualifications:

• BS/BA or MS in Molecular Biology, Biochemistry, Chemical Engineering, Biological Engineering, or related fields
• Industry experience preferred

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

About Flagship Pioneering:

Flagship Pioneering is a biotechnology company that invents and builds platform companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps. Those big leaps in human health and sustainability exponentially accelerate scientific progress in areas ranging from cancer detection and treatment to nature-positive agriculture. What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our scientific founders, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and transform for the benefit of people and planet. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.

Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company's annual list of the World's Most Innovative Companies.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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