Scientist - Immunology

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. Were looking for people who are determined to make life better for people around the world.

As a Sr. Scientist in Immunology, you will support the development of novel allogeneic cell therapies by developing immune cell-based assays, performing in vitro experiments, and assessing immune response to different gene edited cells. You will contribute to the early-stage validation of gene edits and will work closely with cross-functional teams to advance cell therapy programs to preclinical development.

• Develop and optimize cell-based assays using primary human immune cells, such as mixed lymphocyte reaction, T-cell, NK-cell cytotoxicity assays, phagocytosis assays, etc.
• Isolate and culture different immune cells from either PBMCs or fresh whole blood using immunomagnetic isolation techniques.
• Perform differentiation of monocyte to macrophages or dendritic cells, as needed
• Assess immune checkpoint receptor expression using multi-parameter flow cytometry techniques
• Use different gene editing techniques, including CRISPR to create knockouts or transgenic cell lines
• Gene edit different cell types including iPSCs, primary cells, and immortalized cell lines
• Use different methods, including cell sorting, single cell cloning to create gene edited clonal cell lines
• Design and implement experiments and analyze resulting data to evaluate efficacy of gene edited cells in in vitro assays
• Communicate experimental data effectively through written reports and oral presentations.
• Demonstrate flexibility and motivation to learn and apply new technologies for biological assays.

Basic Requirements:

• Bachelors degree in Immunology, Cell Biology, or a related field plus 5 years of relevant experience in biotechnology or pharmaceutical industry OR
• Masters degree in Immunology, Cell Biology, or a related field plus 2 years of relevant experience in biotechnology or pharmaceutical industry

Additional Skills/Preferences:

• Prior experience with using live cell analysis platforms such as Incucyte and Xcelligence will be a plus
• Proficient in developing in vitro assays, including work with human cell lines, PBMCs, and whole blood assays.
• Proven ability to use immune cell and cytokine analytical techniques, including multiplex ELISA, MSD and flow cytometry
• Prior work with CRISPR/Cas9 gene editing techniques.
• Strong analytical, problem-solving, and decision-making skills.
• Excellent interpersonal and communication skills.
• Ability to work independently and collaboratively within a team environment.

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Actual compensation will depend on a candidates education, experience, skills, and geographic location. The anticipated wage for this position is

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lillys compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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