Sr. Associate Scientist-Confocal Imaging

Senior Associate Scientist for Confocal Imaging - Contract role

Position Overview:

Prellis Biologics uses proprietary technology to 3D print lymph node organoids, which we are using to generate in vitro antibody libraries and invitro human lymph node cocultures for generating antigen-specific B-cells. We are seeking a highly motivated Senior Associate Scientist with strong expertise in 3D confocal imaging to join our team on a contract basis. In this role, the individual will be supporting our microscopy efforts of capturing the complex cellular interactions that occur within our artificial lymph node organoids. The ideal candidate will have a strong background in cell biology and experience in the staining, imaging, and analysis of biological samples, particularly in complex 3D tissue structures.

Primary Responsibilities:

• Routinely handle mammalian cell cultures and perform high-quality immunofluorescence staining on biological tissues and samples
• Independently acquire and process 3D confocal images using advanced imaging systems at partner locations
• Conduct quantitative image analysis and present data in a clear, organized manner
• Experience in preparing tissue samples through embedding and cryosectioning is a plus
• Experience in flow cytometry staining and data acquisition on a flow cytometer is a plus
• Maintain detailed, accurate, and timely documentation of all experiments in electronic lab notebooks (ELN)
• Collaborate closely with cross-functional teams to support project goals
• Contribute to data interpretation and troubleshooting efforts as needed

Required Qualifications:

• M.S. in Cell Biology, Molecular Biology, Biomedical Engineering, or a related field
• 2-3 years of hands-on experience in 3D confocal imaging and immunofluorescence staining, ideally on Nikon or Zeiss confocal systems
• Proficient in image analysis software (e.g., ImageJ/Fiji, Imaris, or similar)
• Demonstrated ability to work independently in a laboratory setting
• Familiarity with tissue embedding and cryosectioning is preferred but not required
• Strong organizational skills and excellent attention to detail
• Effective written and verbal communication skills
• Ability to work well both independently and in a collaborative, team-oriented environment
• Proactive, collaborative, and adaptable in a dynamic research setting.

About Prellis Biologics

At Prellis we integrate human biology with machine learning. We aim to revolutionized drug discovery by harnessing the power of human immune system with tightly, integrated machine learning to develop next-generation antibody therapeutics with unparalleled speed, precision and safety. We are committed to empowering our pharmaceutical partners with access to the most promising fully human body candidate rapidly identified from the human immune repertoire, enabling them to bring life-changing treatments to patients faster than ever before.Prellis Biologics is a pre-IPO biotech located in Berkeley CA with a team-oriented, inclusive, and family-friendly culture. Our growing pipeline target high unmet patient needs across therapeutics including metabolic, inflammation, and oncology disease. Prellis has raised funding from top investors, including Celesta, Khosla Ventures, SOSV, & Avidity Partners.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.

Application deadline

Prellis does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Prellis Bio is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams-grounded in a wide range of expertise and life experiences-and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.