Temporary Scientist, Formulation & Fill/Finish

Title: Temporary Scientist, Formulation & Fill/Finish

Manager: Scientist III, Formulation & Fill/Finish

Department: Formulation & Fill/Finish

Location: Brisbane, CA

Sangamo Therapeutics is a genomic medicine company focused on treating debilitating neurological diseases, by using our wholly owned, highly versatile zinc finger epigenetic regulation technology and capsid delivery engine. We are passionate about designing and developing genomic medicines to transform the lives of patients suffering from severe diseases with our deep scientific expertise and proprietary zinc finger genome engineering technology. At Sangamo, we are dedicated to building a robust, sustainable genomic medicine pipeline that addresses life-limiting conditions by replacing today's symptom-focused treatments with tomorrow's genomic cures. Our top priority is to meet the needs of patients with commitment and compassion. Along with our commitment to science and to our patients, we also endeavor to create an inclusive environment that promotes and values diversity. Sangamo is a company where individuals can flourish, grow and develop their expertise.

We are seeking top talent to join our mission. Let's build a better future together.

JOB SUMMARY:

Sangamo Therapeutics is seeking a highly motivated individual with drug product formulation and/or process development experience to contribute to the development of best-in-class viral vector and cell therapy products. The successful candidate will be responsible for the formulation and DP process development of clinical candidates, develop and implement novel biochemical and biophysical methods for product characterization, support process characterization/validation studies, support technical process transfer to internal and external manufacturing sites in support of clinical development and commercialization of Sangamo's internal and partnered programs. They will operate in a matrixed environment and collaborate successfully with colleagues within Technical Operations and cross-unctionally with clinical, external manufacturing, supply chain and commercial groups to drive product and process excellence. This is a temporary position, working onsite in our Brisbane, CA facility. We are only considering candidates local to the San Francisco Bay Area.

ESSENTIAL FUNCTIONS:

• Plan, design and execute univariate/multivariate studies to develop robust and manufacturable formulations and DP processes
• Process data, compile results, report and communicate study findings in the form of presentations, reports and external publications
• Develop and implement novel biochemical and biophysical methods suitable for cell and gene therapy product characterization.
• Lead and/or participate in CMC/project teams for functional representation as well as support teams' objectives and project deliverables.
• Author and review technical protocols and reports to document study findings in support of Investigational New Drug (IND), IND amendments, BLA, as well as global marketing application submissions.
• Partner with internal/external manufacturing and quality for process improvement, transfers, compilation and review of batch records, master production records and technical support to resolve investigations, deviations, corrective/preventative actions.
• Excellent communication and interpersonal skills, with proven ability to work effectively in cross-functional teams to meet project milestones and timelines.
• Scientific curiosity and creative problem-solving skills are highly desirable

EDUCATION, EXPERIENCE AND SKILLS REQUIREMENTS:

• BS/MS/PhD degree in biochemistry, pharmaceutical sciences, biochemical engineering, or related discipline.
• 0 - 2+ years (PhD) or 5+ years (MS/BS) of laboratory experience in biotechnology or pharmaceutical industry.
• Experience with formulation development, DP process design and manufacturing Fill/Finish is highly desirable, however, academic experience related to cell culture, analytical chemistry, viral vectors, or gene therapy will be considered.
• Proficiency with applying chromatographic (HPLC, UPLC, column chromatography) methods, capillary electrophoresis and biophysical techniques (UV-vis, DLS, CD, FTIR, DSC, AUC, Fluorescence, particle analysis, etc.) for formulation characterization
• AAV gene therapy, Cell Therapy & Gene Editing experience is desirable.
• Sound understanding of statistical methods and data analysis tools (e.g. JMP)

OTHER QUALIFICATIONS:

• Team player, with good interpersonal and organizational skills.

We encourage you to apply even if you don't meet all the qualifications. We believe in the value of diverse perspectives and backgrounds, and we welcome candidates who are eager to learn and contribute to our mission.

Sangamo is an equal opportunity employer

Sangamo is committed to fostering belonging for all employees and embraces diversity, equity, and inclusion in recruiting and hiring. All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual's race, color, sex, gender identity, gender expression, religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws.

Pay Range

The anticipated salary range is for candidates who will work in our San Francisco Bay Area work locations. The final salary offered to a successful candidate will be dependent on several factors that may include, but are not limited to, the type and length of experience with the job, type and length of experience within the industry, education, etc. This salary range may not apply to remote positions that work in other states.

Note to External Recruiters: We do not accept unsolicited resumes from any source other than from the candidates themselves. If you wish to be considered for the presentation of candidates, please email .... We will reach out to you directly if there is a business need for your services.

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