Associate Scientist/ Scientist I, Translational Sciences

Associate Scientist/ Scientist I, Translational Sciences

About the Company:

Dren Bio is a privately held, clinical-stage biopharmaceutical company pioneering the discovery and development of first-in-class antibody therapeutics for the treatment of cancer, autoimmune disorders, and other serious diseases. Leveraging our wholly owned technologies, we have built a robust R&D pipeline, including two clinical-stage candidates currently being evaluated across multiple ongoing clinical studies. Our lead clinical candidate, DR-01, is designed to induce antibody-mediated killing of a specific cell type implicated in a range of oncology and autoimmune indications. In addition, we have launched multiple programs from our proprietary Targeted Myeloid Engager and Phagocytosis Platform, a multispecific antibody-based technology engineered to selectively engage a novel phagocytic receptor expressed on myeloid cells (antigen presenting cells) for the targeted depletion of pathologic cells and other disease-causing agents. Data generated using the platform support its broad therapeutic potential, including initial programs focused on oncology, immunology, and neurology. Importantly, multispecific antibodies generated from the platform are specially designed to activate phagocytic mechanisms only in the presence of disease targets, potentially offering a superior safety profile compared to other immunomodulatory therapies. For more information, please visit our website at www.drenbio.com.

Function:

Translational Sciences

Level:

Associate Scientist/Scientist I

Location:

Foster City, CA (moving to San Carlos, CA Sep 2025)

Reporting Manager:

Senior Scientist II, Translational Sciences

About the Opportunity:

Dren Bio is seeking a bright, highly motivated and experienced associate scientist to support translational sciences in the development and implementation of flow cytometry-based immunophenotyping assays for our enhanced ADCC and myeloid engager program for the treatment of hematological cancers, solid tumors and autoimmune disorders. The ideal candidate has extensive experience in flow cytometry, experience with lymphoid and myeloid cell biology and background in the fields of cancer immunology or inflammatory diseases. The candidate will have the opportunity to participate in generating proof of concept translational data to support the advancement of drug candidates to the clinic. In addition, the candidate will be trained in GCP guidelines and will participate in the development, qualification and implementation of immunophenotyping assays for clinical study samples. Future opportunities may include implementation of other translational assays such as immunohistochemistry, immunofluorescence to support ongoing and prospective clinical studies.. Title, compensation and scope of duties will be tailored to the successful candidate's experience.

Role and Responsibilities:

• Participate in the development, qualification, and implementation of cell-based assays (immunophenotyping and receptor occupancy by flow cytometry) to address exploratory endpoints in clinical studies

• Adhere to GCP guidelines and internal SOPs pertaining to the receipt and analysis of clinical samples

• Collaborate with project teams to accomplish the timely delivery of translational data for internal decision making, regulatory submissions or other purposes

• Collaborate with Quality function to provide appropriate oversight for clinical sample testing

• Provide translational support for pipeline projects e.g. by evaluating target/biomarker expression in disease tissue via RNA-seq, IHC/IF, or flow cytometry

• Present data in internal cross-functional or research meetings

Education, Experience and Qualification Requirements:

• BS or MS degree in cell biology, immunology or related field

• 6+ years (for BS) or 4+ years (for MS) of experience for Associate Scientist and 8+ years (for BS) or 6+ years (for MS) of experience for Scientist I in the biopharmaceutical industry.

Core Competencies, Knowledge and Skill Requirements:

• Broad knowledge of immunology and good technical expertise in cellular immunology

• Prior experience with sample handling/processing/analysis in clinical trials is a requirement

• 5+ years of multi-color flow cytometry (at least 12 colors)

• Experience in immunohistochemistry and immunofluorescence is highly desirable

• Knowledge in NGS/proteomics workflow and data interpretation is a plus

• Data processing and analysis software (Flowjo, Graphpad Prism, ImageJ, R, Python)

• Familiar with usage of electronic data documentation system (Veeva, ELN)

• Strong analytical and critical thinking skills with the ability to interpret complex data and highly motivated to learn and support drug development efforts

• Motivated self-starter who can work independently and collaboratively in a dynamic team environment with a proactive attitude

• Excellent written and verbal communication skills

• Ability to work in a fast-paced environment and the flexibility to align daily work with project needs

• Must be well organized, have a strong work ethic, attention to detail and be diligent in data documentation

Salaries, Benefits and Other Employee Perks:

Dren Bio strongly believes in investing in, and rewarding its employees. This philosophy is embodied in the Companys total rewards program, which includes competitive cash compensation, equity incentive awards, and employer-sponsored benefits. The base pay range for this position at commencement of employment is expected to be between $108,000 and $136,000 per year. At Dren Bio, pay ranges are determined by role, level and location. The range displayed in this job posting reflects the minimum and maximum new hire pay for candidates located across all U.S. job markets. Within the range, individual pay will be determined by work location and additional factors, including job-related skills, experience, and relevant education or training. During the hiring process, Dren Bios Human Resources team can share more about the specific pay range based on the candidates market location.

Employment Practices:

Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio does not discriminate against any job applicant on the basis of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state, or local law.