Principal Scientist, Cell Therapy Vector Engineering
- Lowe's
- United, Pennsylvania
- Full Time
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Principal Scientist, Cell Therapy Vector Engineering
Discovery & Pre-Clinical/Clinical Development
Spring House / United States of America
Principal Scientist, Cell Therapy Vector Engineering
Apply now
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Job title
Principal Scientist, Cell Therapy Vector Engineering
Function
Discovery & Pre-Clinical/Clinical Development
Sub function
Biotherapeutics R D
Category
Principal Scientist, Biotherapeutics R D (ST7)
Location
Spring House / United States of America
Date posted
May 07 2026
Requisition number
R-059245
Work pattern
Fully Onsite
This job posting is anticipated to close on May 22 2026. We may however extend this time period, in which case the posting will remain available on www.careers.jnj.com to accept additional applications.
Description
At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com.
As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.
Job Function:
Discovery & Pre-Clinical/Clinical Development
Job Sub Function:
Biotherapeutics R D
Job Category:
Scientific/Technology
All Job Posting Locations:
Spring House, Pennsylvania, United States of America
Job Description:
About Innovative Medicine
Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
Learn more at
We are searching for the best talent for the best Principal Scientist, Cell Therapy Vector Engineering to be in Spring House, PA.
Purpose:
The Principal Scientist, Vector Engineering position in the Cell Therapy Platform & Discovery group of Therapeutics Discovery offers an exciting opportunity to help develop novel Cell & Gene Therapies for unmet medical needs. We are investigating the use of engineered viral vectors for ex vivo and in vivo gene delivery to T cells to treat cancer. We are seeking a highly motivated scientist to own the design and screening of complex payloads to enable next-generation CAR-T cell products. Do you have industry experience building molecular engineering workflows and the ability to thrive in a cross-functional team? Come join us in our mission to build the next generation of Cell & Gene Therapies for Oncology.
You will be responsible for:
Lead the design and experimental selection of genetic payloads with complex architectures (e.g. multiple expression cassettes and regulatory elements)
Build rigorous experimental workflows to establish design rules and methods for delivering complex payloads to primary T cells
Mentor junior colleagues to grow their experimental and analytical skills while establishing best practices within the team
Maintain detailed records and clearly communicate designs and results to enable efficient data-driven decisions in partnership with stakeholders
Contribute to a collaborative, creative, and rigorous culture of scientific discovery
Qualifications:
PhD in Biological Engineering, Synthetic Biology, Immunology, Chemical Engineering, Virology, Biology, or related field with at least 2 years of post-PhD industry experience; or BS/MS in the above fields with 6-8 years of related experience is required
Industry experience with evidence of scientific project leadership is strongly preferred
Experience designing and evaluating multicomponent genetic elements in primary cells is strongly preferred
Required skills: flow cytometry, familiarity with molecular design software (Geneious, Snapgene, Benchling)
Desired skills include: primary T cell culture, molecular biology assays (such as qPCR or ddPCR, Western blot, ELISA), high-throughput screening, familiarity with DNA/RNA sequencing
Experience with lentiviral vector payload design is preferred
Strong critical, scientific, and strategic thinking skills are required
Strong communication and organizational skills, with the ability to independently manage multiple projects in parallel, are required
Demonstrated ability to work collaboratively in cross-functional teams is required
This role is may require up to 10% travel.
Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.
Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (...) or contact AskGS to be directed to your accommodation resource.
Required Skills:
Preferred Skills:
Analytical Reasoning, Biochemistry, Biotechnology, Chemistry, Manufacturing, and Control (CMC), Clinical Research and Regulations, Clinical Trial Designs, Coaching, Critical Thinking, Drug Discovery Development, Emerging Technologies, Molecular Diagnostics, Organizing, Pharmacovigilance, Presentation Design, Process Improvements, Productivity Planning, Scientific Research
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Equal Employment Opportunity Posters | GINA Supplement
Do not sell or share my personal information
Limit the use of my sensitive personal information
Johnson & Johnson and its affiliates 2026
Medicines & therapies
Medical devices & technology
Media
Contact
View saved jobs
0
English
Login
Healthcare areas
News
Investors
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Our company
Search J&J.com
Home
Careers
Jobs
Principal Scientist, Cell Therapy Vector Engineering
Discovery & Pre-Clinical/Clinical Development
Spring House / United States of America
Principal Scientist, Cell Therapy Vector Engineering
Apply now
Save
Share job
Job title
Principal Scientist, Cell Therapy Vector Engineering
Function
Discovery & Pre-Clinical/Clinical Development
Sub function
Biotherapeutics R D
Category
Principal Scientist, Biotherapeutics R D (ST7)
Location
Spring House / United States of America
Date posted
May 07 2026
Requisition number
R-059245
Work pattern
Fully Onsite
This job posting is anticipated to close on May 22 2026. We may however extend this time period, in which case the posting will remain available on www.careers.jnj.com to accept additional applications.
Description
At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com.
As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.
Job Function:
Discovery & Pre-Clinical/Clinical Development
Job Sub Function:
Biotherapeutics R D
Job Category:
Scientific/Technology
All Job Posting Locations:
Spring House, Pennsylvania, United States of America
Job Description:
About Innovative Medicine
Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
Learn more at
We are searching for the best talent for the best Principal Scientist, Cell Therapy Vector Engineering to be in Spring House, PA.
Purpose:
The Principal Scientist, Vector Engineering position in the Cell Therapy Platform & Discovery group of Therapeutics Discovery offers an exciting opportunity to help develop novel Cell & Gene Therapies for unmet medical needs. We are investigating the use of engineered viral vectors for ex vivo and in vivo gene delivery to T cells to treat cancer. We are seeking a highly motivated scientist to own the design and screening of complex payloads to enable next-generation CAR-T cell products. Do you have industry experience building molecular engineering workflows and the ability to thrive in a cross-functional team? Come join us in our mission to build the next generation of Cell & Gene Therapies for Oncology.
You will be responsible for:
Lead the design and experimental selection of genetic payloads with complex architectures (e.g. multiple expression cassettes and regulatory elements)
Build rigorous experimental workflows to establish design rules and methods for delivering complex payloads to primary T cells
Mentor junior colleagues to grow their experimental and analytical skills while establishing best practices within the team
Maintain detailed records and clearly communicate designs and results to enable efficient data-driven decisions in partnership with stakeholders
Contribute to a collaborative, creative, and rigorous culture of scientific discovery
Qualifications:
PhD in Biological Engineering, Synthetic Biology, Immunology, Chemical Engineering, Virology, Biology, or related field with at least 2 years of post-PhD industry experience; or BS/MS in the above fields with 6-8 years of related experience is required
Industry experience with evidence of scientific project leadership is strongly preferred
Experience designing and evaluating multicomponent genetic elements in primary cells is strongly preferred
Required skills: flow cytometry, familiarity with molecular design software (Geneious, Snapgene, Benchling)
Desired skills include: primary T cell culture, molecular biology assays (such as qPCR or ddPCR, Western blot, ELISA), high-throughput screening, familiarity with DNA/RNA sequencing
Experience with lentiviral vector payload design is preferred
Strong critical, scientific, and strategic thinking skills are required
Strong communication and organizational skills, with the ability to independently manage multiple projects in parallel, are required
Demonstrated ability to work collaboratively in cross-functional teams is required
This role is may require up to 10% travel.
Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.
Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (...) or contact AskGS to be directed to your accommodation resource.
Required Skills:
Preferred Skills:
Analytical Reasoning, Biochemistry, Biotechnology, Chemistry, Manufacturing, and Control (CMC), Clinical Research and Regulations, Clinical Trial Designs, Coaching, Critical Thinking, Drug Discovery Development, Emerging Technologies, Molecular Diagnostics, Organizing, Pharmacovigilance, Presentation Design, Process Improvements, Productivity Planning, Scientific Research
Similar jobs
Principal Scientist, Discovery Immunology
Discovery & Pre-Clinical/Clinical Development
Spring House
Save
Senior Scientist, Vector Biology
Discovery & Pre-Clinical/Clinical Development
Cambridge
Save
Principal Scientist, Vector Biology
Discovery & Pre-Clinical/Clinical Development
Cambridge
Save
Careers in innovation, incubation, collaboration and partnerships
Learn how teams of scientists, entrepreneurs and investors are collaborating to transform today's most promising life sciences discoveries into the healthcare breakthroughs of tomorrow.
Careers in North America
Discover career opportunities at J&J locations in the United States and Canada.
Not ready for a new role right now?
No worries. Join our talent community and we'll reach out when we post new jobs that may match your interests and skills so you can apply when the time is right.
Locations
North America
Europe, Middle East & Africa
Asia Pacific
Latin America
Medicines & therapies
Products
Oncology
Neuroscience
Immunology
Cardiopulmonary
Medical devices & technology
Products
Cardiovascular
Orthopaedics
Surgery
Vision
About us
Our company
Medicines & therapies
Medical devices & technology
Careers
Investors
Media
Key links
Terms of use
Privacy
Cookie policy
Customize Cookie Settings
Request disability accommodation
Hiring FAQs
Employment policies
E-Verify
Recruitment fraud notice
Get in touch
Contact us
Equal Employment Opportunity Posters | GINA Supplement
Do not sell or share my personal information
Limit the use of my sensitive personal information
Johnson & Johnson and its affiliates 2026
Job ID: 520823715
Originally Posted on: 5/12/2026
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