Principal Scientist Oligonucleotide Anal

Job Description: Work Your Magic with us! Start your next chapter and join EMD Serono.

Ready to explore, break barriers, and discover more? We know you've got big plans - so do we! Our colleagues across the globe love innovating with science and technology to enrich people's lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.

United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.

This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US.

Your Role:

* Develop, qualify, and troubleshoot chromatographic (HPLC/UPLC) and LCMS based methods for the identification, characterization of Phosphoramidite, Peptides, ASOs, siRNAs and its lipids, peptides and dyes conjugates.
* Developing a LCMS based methods for the identification, characterization, of Antibody (mAb, Fab) and Antibody Oligo conjugates is preferred.

* Demonstrated hands-on experience in analytical characterization of conjugates with a strong analytical mindset. Proficiency in techniques such as LC-MS, Orbitrap, QTOF, RP-HPLC, FPLC, SEC, and IEX.

* Author method development and qualification reports and SOPs for test methods. Evaluate suitability of new methods and oversee method qualification and validation in the external contract testing labs.
* Support analytical sections in regulatory submission documents like INDs and IMPDs.
* Track progress against project timelines, generate regular status updates, and communicate progress and issues to management.
* Conduct laboratory work in safe, efficient manner that ensures a safe working environment for colleagues.

Who You Are

Minimum Qualifications:

* PhD in Chemistry, Biochemistry or related disciplines with relevant industry experience preferred, or master's degree with minimum 7 years related industry with demonstrated chromatographic separation, method development /qualification and structure elucidation expertise.

Preferred Qualifications:

* Experience with HPLC/UPLC and LCMS-based analytical method development desired.
* Hands-on experience with the analysis of Antibody and oligonucleotides and is a plus.
* Familiarity with instrument troubleshooting and software including Empower, Mass Hunter, and UNIFI preferred.
* Knowledge of GxP requirements and application of statistical methods in the analytical laboratory is a plus.
* Strong interpersonal skills, communication, and collaboration.

Location: Billerica MA

Pay Range for this position: $192,000 - $193,400

The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as loc
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*Click on SAVE TO JOB ORDER* Close Date: 2026-07-30
Number of Positions Available: 1