Senior Automation Scientist High Throughput Screening

Use Your Power for Purpose

At Pfizer, our purpose is to deliver breakthroughs that transform patients' lives. Central to this mission is our Research and Development team, dedicated to translating advanced science and innovative technologies into impactful therapies and vaccines. Whether you are engaged in discovery sciences, ensuring the safety and efficacy of drugs, or supporting clinical trials, you will leverage cutting-edge design and process development capabilities. Your efforts will accelerate the delivery of best-in-class medicines to patients globally, fulfilling Pfizer's commitment to making a meaningful difference in healthcare.

What You Will Achieve

We are seeking a Senior Automation Scientist with strong skills in robotics and the use of high throughput screening (HTS) equipment to join our HTS team, within the Discovery Biology and Pharmacology (DBP) group in Groton, CT. The HTS team is building internal capabilities to support automated high-throughput screening to identify novel lead matter in support of Pfizers small molecule portfolio. The successful candidate will combine his/her/their expertise with integrated screening platforms with strong collaboration and organizational skills to partner with colleagues across functions and to support multiple disease areas of focus.

The successful candidate will combine technical and scientific rigor, attention to detail, the ability to predict and maintain timelines, excellent communication skills, and a sense of humor to complete this challenging job with a sense of joy.

Key Responsibilities

The successful candidate will help to build Pfizers internal HTS capability in DBP by designing and executing automated workflows to enable HTS including primary, confirmation, counter screen, and selectivity assays in 384-well and 1536-well plate formats, all with minimal supervision. This scientist will be responsible for integrating various dispensers and readers into our HighRes Bio automation systems, teaching positions, troubleshooting instrument issues, and creating new programs.

Successful candidates will be expected to:

• Independently design automation protocols based on assay requirements established with assay scientists

• Enable the execution of primary screening campaigns in high-throughput, leveraging plate-based assays and automation (384- and 1536-well formats)

• Enable the rapid adaptation of assays to automated protocols including hit confirmation and downstream follow-up screening.

• Program automation systems using Cellario, Biomek, Vworks, Echo, DART, SAMI, etc. for efficient execution of HTS campaigns

• Manage the inventory of automation equipment shared in the DBP group including a variety of dispensers, incubators, plate readers, etc.

• Assist in coordination of instrument maintenance and repairs, planning for replacement when instrumentation becomes obsolete, and creating new methods on online and offline equipment, etc.

• Maintain offline instruments from manufacturers including Biomek, Agilent, Thermo, Revvity, etc.

• Evaluate and implement new technologies into the HTS workflow to ensure that Pfizer stays current in the HTS field. Liaise effectively with project teams to ensure the timely progression of HTS campaigns and to adjust to changing needs.

• Actively participate in the scouting, evaluation and implementation of new instrumentation to enhance workflow efficiencies and/or capabilities.

• Manage robotic system scheduling to optimize usage and ensure screening campaigns are conducted in a timely manner

Qualifications

• PhD or equivalent with 1-3 years relevant laboratory experience, or MSc/BSc with 5 or more years' experience

• Experience providing lab automation support in an in vitro drug discovery group.

• Demonstrated expertise in the use of HighRes automated systems including strong familiarity with Cellario scheduling software

• Expertise in a range of routine plate-based instruments including common HTS liquid handlers (Combi, Echo, Tempest, Biomek tip based systems)

• Familiarity and working knowledge of common HTS readers such as the Pherastar, Envision, High-content systems, qRT-PCR instruments, etc.

• Familiarity with in vitro assay technologies (fluorescence, HTRF, AlphaLISA, nanoBRET, SPA, etc.)

• Ability to troubleshoot issues with common lab equipment

• Ability to collaborate and communicate effectively in a highly matrixed environment to ensure alignment and transparency around HTS timelines and needs.

• Strong ability to interface with external vendors for support.

• Strong attention to detail to ensure robust automation runs to optimize our HTS infrastructure and manage to ambitious timelines while ensuring high-quality screening campaigns

• Proficiency with personal computers, including word processing, spreadsheets, Excel, PowerPoint, and relevant scientific software

• Specific expertise in the study of cell cycle-related Cyclin Dependent Kinases, including direct assessments of cellular activity, localization, and interaction with their molecular networks

• Excellent organizational skills and the ability to manage time effectively

• Strong interpersonal skills and the ability to work collaboratively within a team

PHYSICAL/MENTAL REQUIREMENTS

Sitting, standing, lifting, bending, and walking. Ability to work on a computer (while standing or sitting). Ability to perform mathematical calculations and interpret data.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

• Majority of work will be performed during the standard work day, but ability to work flexible hours when needed is preferrable

• Travel to attend appropriate meetings and conferences

• Compliance with laboratory safety practices

Other Job Details:

• Last Date to Apply: June 10 , 2025.

• Work Location Assignment: On Premise

• No relocation support available

The annual base salary for this position ranges from $90,900.00 to $151,500.00. In addition, this position is eligible for participation in Pfizers Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of lifes moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care providers name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

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