Senior Scientist Dana-Farber Cancer Institute

The Aguirre laboratory at Dana-Farber Cancer Institute and Harvard Medical School studies the genetics and biology of pancreatic cancer, one of the deadliest human cancer types. We utilize variety of molecular biology and genomic approaches to understand GI cancer with three major focus areas: 1) Discovery and validation of the new therapeutic targets in pancreatic cancer; 2) Investigating RAS biology and targeting in pancreatic cancer; and 3) Understanding the genetic and phenotypic subtypes of pancreatic cancer using single cell genomic and transcriptomic analysis of tumor biopsies and patient-derived organoid models. Research in the laboratory ranges from basic mechanistic investigation of cancer gene function or novel small molecule therapeutics to highly translational genomic and functional studies of patient-derived tissues from clinical trials. The Aguirre lab works collaboratively within the Dana-Farber Hale Center for Pancreatic Research, the DFCI Lustgarten Foundation Dedicated Research Lab, the DFCI Center for RAS Therapeutics, and the Broad Institute of Harvard and MIT. Team members include laboratory investigators, clinical investigators and computational biologists at both Dana-Farber Cancer Institute and the Broad Institute.

We are seeking a motivated and collaborative research scientist with expertise in cancer biology and experimental therapeutics evaluation in human patient-derived models, including organoid cultures and PDX models. The successful candidate will also have experience in managing academic-industry collaborations. This individual will coordinate and manage laboratory efforts on both mechanistic studies and collaborative projects. The candidate will work closely with a team of technicians, students, and post-docs to plan experiments as well as to analyze, present and publish research findings.

Aguirre Lab - Pancreatic Cancer Research - Home

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

• Act as a primary liaison with industry partners to support and expand the lab?s strategic alliances with industry
• Coordinate research activities, develop metrics, timelines and endpoints to facilitate successful project planning and execution
• Design and conduct experiments as well as analyze data in support of laboratory projects and clinical trial correlative science studies
• Maintain lab infrastructure and contribute to operational planning.
• Organize and help lead meetings with individual companies to identify novel opportunities for collaboration or report on progress on existing projects in the RAS therapeutics space.
• Collaborate with and mentor other laboratory members
• Contribute to manuscripts and grant applications by organizing data and describing research results
• Contribute to proposal and progress report writing related to collaborative projects

• PhD, MD or MD/PhD in biological sciences or equivalent
• Strong background in molecular and/or cell biology, biochemistry, genomics, cancer biology or computational biology
• One or more years of post-doctoral research experience preferred
• Management responsibility desired
• Outstanding organizational skills and excellent record keeping
• Experience managing research collaborations, especially with industry partners, is required
• Excellent leadership, management, organizational, and communication skills
• Ability to thrive in a fast-paced, team-oriented environment with a shared mission to advance cancer therapeutics
• Strong work ethic, positive attitude, and attention to detail
• Outstanding interpersonal and relationship-building skills
• Ability to manage multiple projects simultaneously

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

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