Postdoctoral Scientist - Antibody-RNA Conjugation, Genetic Medicine

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. Were looking for people who are determined to make life better for people around the world.

We serve an extraordinary purpose. For more than 140 years, we have worked diligently to discover medicines that make life better. These discoveries start in Lilly Research Laboratories, where our scientists work to create new medicines that will help solve our worlds greatest health challenges.

At the Lilly Innovation Center in Boston Seaport, Massachusetts, we explore how next generation therapeutics, new technologies, data analytics and new care models can improve patient health and the healthcare system. Our team in Boston shares a real passion for challenging conventional wisdom and creating an environment that embraces creative, break-through concepts. The Center offers a start-up environment with large company support. It is located in the heart of Massachusetts exploding science and technology cluster and is within walking distance of some of the best academic and industry innovators in the world.

We are seeking a highly motivated postdoctoral fellow to join our Genetic Medicine team at Eli Lilly in Boston MA. The successful candidate will possess a strong background in synthetic organic chemistry and experience in molecular design. They will be responsible for designing, synthesizing, and characterizing novel linkers for drug conjugates, with a focus on effective extrahepatic delivery. As part of a platform team, this individual will formulate linker chemistry strategies and investigate kinetics of payload-linker release to advance the RNA modality. Success in this role requires ability to solve complex problems, challenge the status-quo, and excel in communication and collaboration within a multidisciplinary team-oriented environment.

• Develop novel linker strategies for antibody-RNA conjugates and bioconjugation methodologies. Design and synthesize novel linkers for controlled drug release.
• Collaborate closely with ADME teams to develop robust bioanalytical methods and to investigate PK/PD relationships for antibody-RNA conjugates.
• Contribute to optimization of internal antibody-RNA conjugate workflow.
• Work productively and safely in the laboratory; and maintain good practice in writing experimental reports in an electronic lab notebook.
• Communicate experimental results and project progress with supervisor and at team/department meetings.
• Publish/share original research externally (presentations, peer-reviewed articles, and conferences).

• Ph.D. in synthetic chemistry, chemical biology, or related scientific field with all completed requirements by September 2025.

• Extensive knowledge of cutting-edge modern organic chemistry, linker design and complex molecule synthesis.
• Understanding advanced analytical and purification techniques.
• Experience in antibody-drug conjugates and/or oligonucleotide chemistry will be preferred.
• Proficiency in independently executing research tasks.
• High learning agility in the field of new scientific concepts and drug modalities.
• Strong problem-solving skills with creative solutions in constructing complex molecular systems.
• A proven track record of significant contributions to research projects, substantiated by first or co-authorship on peer-reviewed scientific publications.
• A track record of productive collaborations in interdisciplinary team environment.
• Excellent communication and organizational skills

• This position is not permanent. It is for a fixed duration of two years with potential to extend to 3 years and for maximum of up to 4 years. You will have opportunities to apply for full time positions after your duration is complete

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Actual compensation will depend on a candidates education, experience, skills, and geographic location. The anticipated wage for this position is

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lillys compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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